Collective cell migration: Implications for wound healing and cancer invasion.
Collective cell migration: Implications for wound healing and cancer invasion.
复制标题
集体细胞迁移：对伤口愈合和癌症侵袭的影响。
DOI：
10.4103/2321-3868.113331
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发表时间：
2013
期刊：
影响因子：
5.3
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Li L;He Y;Zhao M;Jiang J
在胚胎形态发生、伤口修复和肿瘤侵袭过程中，细胞往往通过紧密的细胞-细胞连接集体迁移，这一过程被称为集体迁移。在这种迁移过程中，细胞以连贯的群体、大的细胞片、链或管的形式移动，而不是单独移动。关于集体细胞迁移的一个意想不到的发现是，与孤立的细胞相比，作为一种“多细胞结构”，细胞能够更好地对化学和物理线索做出反应。这一点很重要，因为上皮细胞通过迁移具有紧密细胞间连接的大片细胞来愈合伤口。最近的研究已经获得了一些机制上的见解，这将有助于临床对伤口愈合的总体理解。在这篇综述中，我们将简要介绍集体细胞迁移在伤口愈合、再生和癌症侵袭中的作用，并讨论其潜在的机制以及对伤口愈合的影响。
During embryonic morphogenesis, wound repair and cancer invasion, cells often migrate collectively via tight cell-cell junctions, a process named collective migration. During such migration, cells move as coherent groups, large cell sheets, strands or tubes rather than individually. One unexpected finding regarding collective cell migration is that being a “multicellular structure” enables cells to better respond to chemical and physical cues, when compared with isolated cells. This is important because epithelial cells heal wounds via the migration of large sheets of cells with tight intercellular connections. Recent studies have gained some mechanistic insights that will benefit the clinical understanding of wound healing in general. In this review, we will briefly introduce the role of collective cell migration in wound healing, regeneration and cancer invasion and discuss its underlying mechanisms as well as implications for wound healing.