Regulation of dendritic growth and plasticity by local and global calcium dynamics
Regulation of dendritic growth and plasticity by local and global calcium dynamics
复制标题
DOI：
10.1016/j.ceca.2005.01.008
复制
发表时间：
2005-05-01
期刊：
影响因子：
4
通讯作者：
Wong, ROL
中科院分区：
文献类型：
--
作者：
Lohmann, C;Wong, ROL
神经元的树突被组织成独特的空间模式，非常适合其特定的功能。虽然在发育过程中决定树突乔木大小和分支模式的细胞内信号传导途径尚未完全了解，但很明显，神经传递介导的细胞内钙水平升高（[Ca2+]（i））起着重要作用。钙成像和遗传学方法的最新进展为钙如何调节树突状细胞的生长和重塑提供了新的见解。在神经元去极化后发生的[Ca 2 +]（i）的整体增加通过调节转录来控制树突状乔木的生长。然而，树突状乔木的详细分支模式由局部钙信号调节。细胞内储存的钙诱导钙释放（CICR）起到局部稳定树枝状分支的作用，推测是由与新建立的输入接触后的神经传递触发的。[Ca2+]（i）的整体和局部增加对树突结构的影响是细胞类型和年龄依赖性的。解开由局部和全局[Ca2+]（i）上升引起的信号通路，该信号通路在每个发育阶段形成发育中的树突状乔木，这仍然具有挑战性，但非常重要。(c)2005爱思唯尔有限公司保留所有权利。
The dendritic arbors of neurons are organized into unique spatial patterns that are well suited for their specific functions. Although the intracellular signaling pathways that determine dendritic arbor size and branching patterns during development are not completely understood, it is evident that neurotransmission-mediated elevation in intracellular calcium levels ([Ca2+](i)) plays a major role. Recent advances in calcium imaging and genetic approaches have provided new insight into how calcium acts to regulate dendritic growth and remodeling. Global increases in [Ca2+](i) that occur upon neuronal depolarization control dendritic arbor growth by regulating transcription. However, the detailed branching patterns of dendritic arbors are regulated by local calcium signaling. Calcium-induced calcium release (CICR) from intracellular stores acts to locally stabilize dendritic branches, presumably triggered by neurotransmission upon contact with newly established inputs. The effects of global and local increases in [Ca2+](i) on dendritic structure are cell type- and age-dependent. Unraveling the signaling pathways evoked by local and global rises in [Ca2+](i) that shape the developing dendritic arbor at each developmental stage remains challenging but highly important. (c) 2005 Elsevier Ltd. All rights reserved.