SENSITIVITY AND SPECIFICITY OF 1ST SCREEN MAMMOGRAPHY IN THE CANADIAN NATIONAL BREAST SCREENING STUDY - A PRELIMINARY-REPORT FROM 5 CENTERS
SENSITIVITY AND SPECIFICITY OF 1ST SCREEN MAMMOGRAPHY IN THE CANADIAN NATIONAL BREAST SCREENING STUDY - A PRELIMINARY-REPORT FROM 5 CENTERS
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DOI：
10.1148/radiology.160.2.3523590
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发表时间：
1986-08-01
期刊：
影响因子：
19.7
通讯作者：
STANDING, HK
中科院分区：
文献类型：
--
作者：
BAINES, CJ;MILLER, AB;STANDING, HK
报告了五个中心的随机筛查试验中首次筛查乳房 X 光检查的敏感性和特异性。共有 23,101 名女性接受了乳房 X 光检查； 139 人在第一次筛查时发现乳腺癌； 20岁，首次筛查后不到12个月； 47，第二次筛选。所有 206 例癌症病例均经过组织学证实，其中 174 例被定义为在首次筛查时可检测到。所有女性的平均随访时间为 3.2 年。中心放射科医生对第一屏幕乳房X光检查的解释与已知结果相匹配。由一位参考放射科医生同时对所有 206 例癌症病例和 739 名在初次筛查后 15 个月或更长时间内未知患有乳腺癌的女性随机样本进行乳房 X 光检查。总体而言，五个筛查中心的敏感性为 69%（范围为 60%-78%），特异性为 94%（范围为 93%-96%），阳性预测值为 8.6%（范围为 3%-16%），阴性预测值为 99.7%（范围为 99.6%-99.9%）。
Sensitivity and specificity of first screen mammography in a randomized screening trial at five centers are reported. A total of 23,101 women underwent mammography; in 139, breast cancer was detected at first screening; in 20, less than 12 months after first screening; and in 47, at second screening. All 206 cancer cases were histologically confirmed, and 174 were defined as being detectable at first screening. Average length of follow-up for all women was 3.2 years. Interpretations of first screen mammograms by the center radiologists were matched to known outcomes. Simultaneous blind review was performed by a single reference radiologist with mammograms from all 206 cancer cases and those of a random sample of 739 women not known to have breast cancer at 15 months or more after initial screening. Overall, the five screening centers achieved a sensitivity of 69% (range, 60%-78%), a specificity of 94% (range, 93%-96%), a positive predictive value of 8.6% (range, 3%-16%), and a negative predictive value of 99.7% (range, 99.6%-99.9%).