Modification in growth of transplantable rat tumors exposed to Friend virus.
Modification in growth of transplantable rat tumors exposed to Friend virus.
复制标题
暴露于弗兰德病毒的可移植大鼠肿瘤生长的改变。
DOI：
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发表时间：
1969
期刊：
影响因子：
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通讯作者：
H. Saito
中科院分区：
文献类型：
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作者：
Hiroshi Kobayashi;F. Sendo;Toshikazu Shirai;H. Kaji;T. Kodama;H. Saito
暴露于Friend病毒的三种可移植肿瘤细胞系（WST-5肉瘤、Takeda肉瘤和DLT肺癌）移植到易感大鼠体内的成功率较低，即使完成移植，肿瘤细胞也会自发消退。在这3个品系中，武田肉瘤的快速生长速率导致宿主的早期死亡，并且不能总是辨别出Friend病毒感染的影响。然而，当宿主之前接种过Friend病毒时，其效果变得与其他两条线一样明显。这不是因为大鼠肿瘤细胞表现出Friend病毒的细胞病变效应，也不是因为Friend病毒接种引起宿主环境的改变，而是可能因为Friend病毒感染导致肿瘤细胞表面产生Friend病毒相关抗原。使用非致细胞病变病毒的意义，它改变了肿瘤细胞的表面，对宿主的感染性太弱，不能改变肿瘤的生长，进行了讨论。J Nat Cancer Inst 42：413- 419，1969.
Three transplantable tumor cell lines (WST-5 sarcoma, Takeda sarcoma, and DLT I ung carcinoma) exposed to Friend virus had a low success rate of transplantation into susceptible rats, and even when transplantation was accomplished, the tumor cells regressed spontaneously. Of the 3 lines, the rapid growth rate of the Takeda sarcoma resulted in early death of the host, and the effect of infection with Friend virus could not always be discerned. When the host was previously immunized with Friend virus, however, the effect became as clearly discernible as in the two other lines. This was not because the rat tumor cell showed the cytopathic effect of Friend virus nor because of the environmental change of the host brought about by Friend virus inoculation, but was probably because of the production of Friend virus-related antigen on the surface of the tumor cell resulting from Friend virus infection. The significance of using a noncytopathic virus, which altered the surface of tumor cells and which was too weakly infectious to the host to modify the growth of tumor, is discussed.-J Nat Cancer Inst 42: 413-419,1969.