fMRI reactivity on a delay discounting task predicts weight gain in obese women
fMRI reactivity on a delay discounting task predicts weight gain in obese women
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DOI：
10.1016/j.appet.2011.11.029
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发表时间：
2012-04-01
期刊：
影响因子：
5.4
通讯作者：
Weller, Rosalyn E.
中科院分区：
文献类型：
--
作者：
Kishinevsky, Felix I.;Cox, James E.;Weller, Rosalyn E.
肥胖可能伴随着执行功能和相关神经回路的异常。研究执行功能的一个有用的任务是延迟贴现（DD），其中一个人在更早和更晚之间选择，但更多的钱或其他商品。我们之前发现，与正常体重的女性相比，肥胖女性在金钱DD任务中做出了更直接的选择，或者有更大的延迟折扣。在本研究中，我们进行了功能性磁共振成像（fMRI）的肥胖妇女在执行DD的钱的任务。回顾以前的研究结果，我们发现，更困难的DD试验相比，容易导致激活假定的执行功能区的大脑，中，额下回，内侧前额叶皮层。最有趣的是，我们还发现，在困难与简单的DD试验中，执行功能区域（如额下回、额中回和额上级回）的激活较少，预示着随后1.3-2.9年的体重增加率更高。这些结果表明，执行功能区域（如前额皮质）的次优功能有助于肥胖的进展。(C)2011爱思唯尔有限公司保留所有权利。
Obesity can be accompanied by abnormalities in executive function and related neural circuitry. A useful task for studying executive function is delay discounting (DD), in which an individual chooses between sooner and delayed, but greater, amounts of money or other commodities. We previously found that obese compared to normal-weight women made more immediate choices on a monetary DD task, or had greater delay discounting. In the present study, we performed functional magnetic resonance imaging (fMRI) of obese women during performance of a DD of money task. Confirming the results of previous studies, we found that more difficult compared to easy DD trials resulted in activation in putative executive function areas of the brain, the middle and inferior frontal gyri, and medial prefrontal cortex. Most interestingly, we also found that less activation in executive function areas such as the inferior, middle, and superior frontal gyri on difficult vs. easy DD trials predicted a greater rate of weight gain over the subsequent 1.3-2.9 years. These results suggest that suboptimal functioning of executive function areas such as prefrontal cortex contributes to the progression of obesity. (C) 2011 Elsevier Ltd. All rights reserved.