THE HIGH-INCIDENCE OF ATRIAL THROMBOSIS IN MICE GIVEN DOXORUBICIN
THE HIGH-INCIDENCE OF ATRIAL THROMBOSIS IN MICE GIVEN DOXORUBICIN
复制标题
DOI：
10.1177/019262339302100403
复制
发表时间：
1993-01-01
影响因子：
1.5
通讯作者：
MORI, H
中科院分区：
文献类型：
--
作者：
FUJIHIRA, S;YAMAMOTO, T;MORI, H
阿霉素(DX)治疗的小鼠代表了研究心脏病新药的动物模型。巧合的是，在收集的受损心肌组织中，发现了心房血栓形成。小鼠静脉注射4 mg/kg DX 10次，发病率达75%。它们是由纤维蛋白、血小板和中性粒细胞组成的白色血栓。心肌损伤在心房比在脑室更明显。光镜下可见心房肌细胞空泡化、变性，间质炎性细胞浸润。电子显微镜显示肌浆网扩张，正常和/或退化的线粒体数量增加。炎症从心肌蔓延到心内膜。DX治疗的小鼠心房血栓形成的原因尚不清楚，但可能与心内膜损伤和继发于心肌损伤的心房血流变化有关。DX处理的小鼠可作为评价抗血栓药物或抗血小板药物疗效和毒性的实验动物模型。
Doxorubicin (DX)-treated mice represent an animal model for studying new drugs for heart disease. Coincidentally, in the collection of damaged myocardial tissue, thrombosis was detected in the atrium. The incidence reached 75% in mice given 4 mg/kg DX iv 10 times. They were white thrombi consisting of the fibrin, platelets, and neutrophils. Cardiac muscle damage was more prominent in the atria than in the ventricles. Light microscopically, vacuolization and degeneration of atrial myocytes and interstitial inflammatory cell infiltration were observed. Electron microscopy revealed dilatation of the sarcoplasmic reticulum and an increase in number of normal and/or degenerate mitochondria. Inflammation extended from the cardiac muscle to the endocardium. The cause of atrial thrombosis in DX-treated mice is unknown but may relate to endocardial damage and changes of blood flow in the atrium secondary to cardiac muscle damage. DX-treated mice could serve as an experimental animal model for the evaluation of efficacy and toxicity of antithrombotic or antiplatelet drugs.