The prevalence of the metabolic syndrome in a Danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population
The prevalence of the metabolic syndrome in a Danish population of women with previous gestational diabetes mellitus is three-fold higher than in the general population
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DOI：
10.1210/jc.2004-1713
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发表时间：
2005-07-01
影响因子：
5.8
通讯作者：
Damm, P
中科院分区：
文献类型：
--
作者：
Lauenborg, J;Mathiesen, E;Damm, P
内容：糖尿病和肥胖是代谢综合征的组成部分，是妊娠糖尿病（GDM）妇女的常见特征。由于糖尿病和肥胖症的发病率增加，代谢综合征可能是这些妇女的主要健康问题。目的是通过三种不同的标准估计代谢综合征的患病率[世界卫生组织1999（WHO），国家胆固醇教育计划专家小组关于成人高血胆固醇的检测、评估和治疗，2001年，设计：我们进行了一项随访研究的丹麦队列妇女承认在1978年至1996年的糖尿病和妊娠中心，Rigshos-pitalet，哥本哈根大学医院，饮食治疗的GDM。随访时间为2000-2002年，平均随访时间为妊娠后9.8年（四分位距6.4-17.2）。结果与对照组的1000名年龄匹配的妇女从人口为基础的样本（Inter 99）进行了比较。（四分位数范围38-48）参与。主要结果测量：主要结果测量是体重指数（BMI）、葡萄糖耐量、血压、血脂和胰岛素抵抗。与标准无关，与对照组相比，既往GDM组的代谢综合征患病率高3倍（例如WHO：38.4% vs. 13.4%，P < 0.0005）。既往GDM组与对照组相比，WHO定义的代谢综合征的BMI和BMI校正比值比为3.4（95%置信区间2.5-4.8）。肥胖妇女（BMI > 30 kg/m2）与正常体重的GDM妇女（BMI < 25 kg/m2）相比，有GDM病史的肥胖妇女代谢综合征（WHO）患病率增加7倍以上。在葡萄糖耐量的妇女，患病率增加了一倍，在先前的GDM组，与control group.Conclusion相比：代谢综合征的患病率是三倍高的妇女与先前的饮食治疗GDM，与年龄匹配的对照组。
Context: Diabetes and obesity, components of the metabolic syndrome, are common characteristics of women with prior gestational diabetes mellitus (GDM). Due to increasing incidence of diabetes and obesity, the metabolic syndrome might comprise a major health problem among these women.Objective: The objective was to estimate the prevalence of the metabolic syndrome by three different criteria [World Health Organization 1999 (WHO), The National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults 2001, and European Group for the Study of Insulin Resistance 2002] among women with previous GDM.Design: We conducted a follow-up study of a Danish cohort of women admitted in 1978-1996 to the Diabetes and Pregnancy Center, Rigshos-pitalet, Copenhagen University Hospital, with diet-treated GDM. The follow-up took place in 2000-2002 at median 9.8 yr (interquartile range 6.4-17.2) after pregnancy. Results were compared with a control group of 1000 age-matched women from a population-based sample (Inter99).Participants: Four hundred eighty-one women at median age 43 yr ( interquartile range 38-48) participated.Main Outcome Measures: The main outcome measures were body mass index (BMI), glucose tolerance, blood pressure, lipid profile, and insulin resistance.Results: Independent of the criteria, the prevalence of the metabolic syndrome was three times higher in the prior GDM group, compared with the control group (e.g. WHO: 38.4 vs. 13.4%, P < 0.0005). Age-and BMI-adjusted odds ratio for having the WHO-defined metabolic syndrome was 3.4 ( 95% confidence interval 2.5-4.8) for the prior GDM group vs. the control group. Obese women (BMI > 30 kg/m(2)) with previous GDM had a more than 7-fold increased prevalence of the metabolic syndrome (WHO), compared with normal-weight prior GDM women (BMI < 25 kg/m(2)). In glucose-tolerant women, the prevalence was doubled in the prior GDM group, compared with control group.Conclusion: The prevalence of the metabolic syndrome was three times as high in women with prior diet-treated GDM, compared with age-matched control subjects.