ROLE OF B61, THE LIGAND FOR THE ECK RECEPTOR TYROSINE KINASE, IN TNF-ALPHA-INDUCED ANGIOGENESIS
ROLE OF B61, THE LIGAND FOR THE ECK RECEPTOR TYROSINE KINASE, IN TNF-ALPHA-INDUCED ANGIOGENESIS
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DOI：
10.1126/science.7536959
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发表时间：
1995-04-28
期刊：
影响因子：
56.9
通讯作者：
DIXIT, VM
中科院分区：
文献类型：
--
作者：
PANDEY, A;SHAO, HN;DIXIT, VM
B61是一种细胞因子诱导的内皮基因产物，是ECK受体蛋白酪氨酸激酶(RPTK)的配基。B61免疫球蛋白嵌合体的表达表明，B61在体内可以作为血管生成因子，在体外对内皮细胞具有趋化作用，肿瘤坏死因子-α(TNF-α)通过诱导B61激活Eck RPTK，B61的抗体减弱了TNF-α诱导的血管生成，但不受碱性成纤维细胞生长因子的影响。这一发现表明，炎症刺激后Eck RPTK和B61存在自分泌或旁分泌环，其净作用是促进血管生成。是慢性炎症的标志，
B61, a cytokine-inducible endothelial gene product, is the ligand for the Eck receptor protein tyrosine kinase (RPTK), Expression of a B61-immunoglobulin chimera showed that B61 could act as an angiogenic factor in vivo and a chemoattractant for endothelial cells in vitro, The Eck RPTK was activated by tumor necrosis factor-alpha (TNF-alpha) through induction of B61, and an antibody to B61 attenuated angiogenesis induced by TNF-alpha but not by basic fibroblast growth factor, This finding suggests the existence of an autocrine or paracrine loop involving activation of the Eck RPTK by its inducible ligand B61 after an inflammatory stimulus, the net effect of which would be to promote angiogenesis, a hallmark of chronic inflammation,