Atherosclerosis: Aortic lipid changes induced by diets suggest diffuse disease with focal severity in primates that model human atheromas
Atherosclerosis: Aortic lipid changes induced by diets suggest diffuse disease with focal severity in primates that model human atheromas
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DOI：
10.1016/s0899-9007(97)00388-2
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发表时间：
1998-01-01
期刊：
影响因子：
4.4
通讯作者：
Kritchevsky, D
中科院分区：
文献类型：
--
作者：
Fincham, JE;Benade, AJS;Kritchevsky, D
黑长尾猴或非洲绿猴（Cercopithecus aethiops）的动脉粥样硬化模拟了人类疾病的形态学和细胞学，并且众所周知，黑长尾猴的动脉粥样硬化发生率受到饮食的影响。已知是动脉粥样硬化主要成分的脂质和磷脂的主动脉内膜浓度是在以致动脉粥样硬化（AD）或谨慎的西方饮食（PD）喂养4年的雌性黑长尾猴中测定的。生物化学证实了可通过显微镜检测的胆固醇晶体和泡沫细胞的脂质浓度。此外，AD 与整个主动脉组织中弥漫性、不可见的脂质积累有关，以至于没有脂肪条纹或斑块 (AD) 的组织含有与可见脂肪条纹 (PD) 相同或更多的脂质。脂质浓度与动脉粥样硬化之间呈高度正相关，这支持了动脉粥样硬化形成过程中主动脉、血浆和膳食脂质之间已知的相关性，并验证了主动脉脂质分析。这些主动脉脂质浓度结果意味着动脉粥样硬化并不局限于局部病理解剖学，但就疾病的脂质成分而言，它在旧大陆杂食灵长类动物的整个动脉系统中发展。如果结果适用于人类，它们将提供新的见解，并强调需要尽量减少导致动脉粥样硬化的脂质的饮食来源。 (C) 爱思唯尔科学公司 1998。
Atherosclerosis in Velvet or African Green monkeys (Cercopithecus aethiops) models the morphology and cytology of the disease of humans, and it is well established that the rate of atherogenesis in Vervets is influenced by diet. Aortic intimal concentrations of lipids and phospholipids known to be major components of atheromas were determined in female Vervets fed for 4 years on either an atherogenic (AD) or a prudent Western diet (PD). Lipid concentrations detectable microscopically as cholesterol crystals and foam cells were confirmed biochemically. In addition, the AD was associated with diffuse, invisible accumulation of lipids throughout aortic tissue to the extent that tissue with no fatty streaks or plaque (AD) contained the same or more lipids than visible fatty streaks (PD). Correlations between lipid concentrations and atherosclerosis were highly positive, which supports known correlations between aortic, plasma, and dietary lipids during atherogenesis, and validates the aortic lipid analysis. These aortic lipid concentration results imply that atherosclerosis is not confined to focal pathologic anatomy, but in terms of lipid components of the disease, it develops throughout the arterial system of Old World omnivorous primates. If the results are applicable to people, they provide new insight and emphasize the need to minimize dietary sources of atherogenic lipids. (C) Elsevier Science Inc. 1998.