Intracellular signaling pathways regulating pluripotency of embryonic stem cells.
Intracellular signaling pathways regulating pluripotency of embryonic stem cells.
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DOI：
10.2174/157488806775269061
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发表时间：
2006-01-01
影响因子：
2.7
通讯作者：
Yamanaka, Shinya
中科院分区：
文献类型：
--
作者：
Okita, Keisuke;Yamanaka, Shinya
细胞因子LIF及其下游效应子STAT 3对于维持小鼠ES细胞的多能性是必不可少的。ES细胞多能性对转录因子Oct 3/4的需求也有充分的记载。然而，LIF不参与人类ES细胞的自我更新，这表明其他途径必须在这一过程中发挥重要作用。其他信号转导途径的重要性，包括BMP和Wnt信号，以及新的转录因子，如Nanog，现在正在被认识到。我们将回顾在识别和解剖有助于多能小鼠和人类ES细胞自我更新的细胞内信号通路方面取得的快速进展。
The cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is also well-documented. However, LIF is not involved in self-renewal of human ES cells, suggesting that other pathways must play an important role in this process. The importance of other signal transduction pathways, including BMP and Wnt signalings, as well as novel transcription factors such as Nanog, is now being recognized. We will review the rapid progress that has been made in identifying and dissecting the intracellular signaling pathways that contribute to self-renewal of pluripotent mouse and human ES cells.