THE EFFECT OF ORAL PROTEIN AND GLUCOSE FEEDING ON SPLANCHNIC BLOOD FLOW AND OXYGEN UTILIZATION IN NORMAL AND CIRRHOTIC SUBJECTS
THE EFFECT OF ORAL PROTEIN AND GLUCOSE FEEDING ON SPLANCHNIC BLOOD FLOW AND OXYGEN UTILIZATION IN NORMAL AND CIRRHOTIC SUBJECTS
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口服蛋白质和葡萄糖喂养对正常和肝硬化受试者内脏血流和氧利用的影响
DOI：
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发表时间：
1955
期刊：
影响因子：
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通讯作者：
A. Jones
中科院分区：
文献类型：
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作者：
J. L. Brandt;L. Castleman;H. Ruskin;J. Greenwald;John J. Kelly;A. Jones
本研究的受试者是来自金斯县医院大学服务部医学病房的患者。共研究了40例患者。14名从最近的急性感染或其他轻微疾病中恢复的患者，根据通常的临床和实验室标准被认为肝功能正常，作为对照组。治疗组26例。21例患者有长期过量饮酒和营养不良的病史; 5例患者在发病前数年有急性肝炎病史。所有病例的肝硬化诊断都得到了实验室检查的支持，15例受试者的肝活检也得到了支持。其中10名患者有腹水，在研究前24小时进行了腹腔穿刺，以便在研究期间尽可能“干燥”。在空腹至少12小时后的早晨，以及摄入蛋白质或葡萄糖后90分钟内的可变时间段内，测定所有受试者的估计内脏血流量（ESBF）和内脏耗氧量（SOC）。用溴磺酞（BSP）法测定内脏血流量（3）。BSP（溶于0.85%生理盐水）以恒定速率静脉输注，少数情况下通过隧道夹维持，其余情况下通过校准的Bowman泵维持。调整了输注速率，
The subjects for this investigation were patients from the Medical Wards of the University Service, Kings County Hospital. A total of 40 patients were studied. Fourteen patients who had recovered from recent acute infections or other minor illnesses and were considered to have normal liver function by the usual clinical and laboratory criteria, served as a control group. There were 26 subjects in the cirrhotic group. Twenty-one of these cirrhotic patients had a history of prolonged excessive alcoholic intake and poor nutrition; 5 had a history of acute hepatitis years previous to the onset of their present illness. The diagnosis of cirrhosis was supported by laboratory studies in all cases, and in 15 subjects by liver biopsy. Ten of the cirrhotic patients had ascites and paracenteses were performed 24 hours before study so that they were as "dry" as possible during the study. The estimated splanchnic blood flow (ESBF) and splanchnic oxygen consumption (SOC) were determined in all subjects in the morning after a fast of at least 12 hours, and for variable periods up to 90 minutes following the ingestion of either protein or glucose. The splanchnic blood flow was determined by the bromsulfalein (BSP) method (3). An infusion of BSP (in 0.85 per cent saline) was administered intravenously at a constant rate maintained in a few instances by a tunnel clamp and in the remaining cases by a calibrated Bowman pump. The rate of infusion was adjusted so