Gastric adenocarcinoma of fundic gland type: report of three cases.
Gastric adenocarcinoma of fundic gland type: report of three cases.
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DOI：
10.4132/koreanjpathol.2012.46.3.287
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发表时间：
2012-06
影响因子：
--
通讯作者：
Kim KM
中科院分区：
文献类型：
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作者：
Park ES;Kim YE;Park CK;Yao T;Kushima R;Kim KM
胃底腺型胃腺癌（GA-FG）是近年来报道的一种新类型。本报告首次描述了韩国人中的GA-FG。从2008年3月到2010年7月，我们在通过内窥镜或手术切除的6,000多例GA中仅发现了3例GA-FG。通过粘蛋白、胃蛋白酶原-I和H+/K+-ATP酶评价细胞分化。3例均为男性患者，诊断为早期GA。组织学上，GA-FG是高分化腺癌，具有浅灰蓝色、嗜碱性柱状或立方细胞和轻度增大的核，类似于主细胞。所有三例胃蛋白酶原-I阳性，并被归类为胃粘蛋白表型。在GA-FG的三种组织学亚型中，由于肿瘤主要由主细胞组成，我们的三个病例被归类为主细胞为主型。总之，GA-FG是非常罕见的韩国人和胃蛋白酶原-I和MUC 6的表达是典型的免疫组化结果，在GA-FG表明分化向胃底腺。
Recently, fundic gland type gastric adenocarcinoma (GA-FG) has been reported as a new entity. This report describes GA-FG among Koreans for the first time. From March 2008 to July 2010 we identified only three cases of GA-FG out of over 6,000 GAs resected by endoscopy or surgery. Cell differentiation by mucin proteins, pepsinogen-I, and H+/K+-ATPase was evaluated. All three cases were male patients and diagnosed as early stage GA. Histologically, GA-FGs were well-differentiated adenocarcinoma with pale gray-blue, basophilic columnar or cuboidal cells and mildly enlarged nuclei, resembling chief cells. All three cases were positive for pepsinogen-I and were classified as gastric mucin phenotype. Among three histologic subtypes of GA-FG, since tumors were mainly composed of chief cells, our three cases were classified as chief cell predominant type. In conclusion, GA-FG is very rare among Koreans and pepsinogen-I and MUC6 expression are typical immunohistochemical findings in GA-FG suggesting differentiation toward fundic glands.