Precision size and refractive index analysis of weakly scattering nanoparticles in polydispersions.
Precision size and refractive index analysis of weakly scattering nanoparticles in polydispersions.
复制标题
DOI：
10.1038/s41592-022-01460-z
复制
发表时间：
2022-05
期刊：
影响因子：
48
通讯作者：
Sandoghdar, Vahid
中科院分区：
文献类型：
--
作者：
Kashkanova, Anna D.;Blessing, Martin;Gemeinhardt, Andre;Soulat, Didier;Sandoghdar, Vahid
Characterization of the size and material properties of particles in liquid suspensions is in very high demand, for example, in the analysis of colloidal samples or of bodily fluids such as urine or blood plasma. However, existing methods are limited in their ability to decipher the constituents of realistic samples. Here we introduce iNTA as a new method that combines interferometric detection of scattering with nanoparticle tracking analysis to reach unprecedented sensitivity and precision in determining the size and refractive index distributions of nanoparticles in suspensions. After benchmarking iNTA with samples of colloidal gold, we present its remarkable ability to resolve the constituents of various multicomponent and polydisperse samples of known origin. Furthermore, we showcase the method by elucidating the refractive index and size distributions of extracellular vesicles from Leishmania parasites and human urine. The current performance of iNTA already enables advances in several important applications, but we also discuss possible improvements. iNTA combines interferometric detection of scattering with nanoparticle tracking analysis for determining the size and refractive index distributions of nanoparticles in suspension with high sensitivity and precision.
登录
查看更多内容
影响因子：
--
作者：
MALITSON, IH
通讯作者：
MALITSON, IH
DOI：
10.1073/pnas.1521230113
发表时间：
2016-02-23
影响因子：
11.1
作者：
Kowal, Joanna;Arras, Guillaume;Thery, Clotilde
通讯作者：
Thery, Clotilde
影响因子：
3.1
作者：
Leitherer, Sabine;Clos, Joachim;Soulat, Didier
通讯作者：
Soulat, Didier
影响因子：
2.7
作者：
Malloy, Andrew;Carr, Bob
通讯作者：
Carr, Bob
影响因子：
4.6
作者：
Brennan, K.;Martin, K.;Mc Gee, M. M.
通讯作者：
Mc Gee, M. M.