E-cadherin is expressed by mono- and multinucleated histiocytes in cutaneous sarcoidal and foreign body granulomas.
E-cadherin is expressed by mono- and multinucleated histiocytes in cutaneous sarcoidal and foreign body granulomas.
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DOI：
10.1097/dad.0b013e31828de7e0
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Schaffer A
中科院分区：
文献类型：
--
作者：
Wanat KA;Rosenbach M;Zoiber AF;Zhang PJ;Schaffer A
E-cadherin, a member of the cadherin family of transmembrane adhesion receptors, is critical for cutaneous barrier function as it promotes keratinocyte and Langerhans cell adhesion in the epidermis. Recent murine models of chronic inflammation identified new E-cadherin-expressing subsets of mononuclear phagocytes, including alternatively activated macrophages and selected inflammatory dendritic cells. It has been shown in vitro that expression of E-cadherin by murine macrophages promotes their homotypic aggregation and fusion to multinucleated giant cells, a signature cell type of granulomatous inflammation. The purpose of our study was to assess E-cadherin expression on histiocytes and giant cells in cutaneous granulomas in human. E-cadherin expression was evaluated by immunohistochemistry of formalin fixed paraffin-embedded skin biopsies of foreign body granulomas (n=21) and sarcoidosis (n=21). The results showed consistent membranous E-cadherin staining pattern on mononucleated histiocytes and multinucleated giant cells in both granuloma types. These E-cadherin expressing histiocytes are distinct from dermal Langerhans cells as they lacked CD1a expression. Our findings suggest that E-cadherin expressing mononuclear histiocytes are likely precursors for multinucleated giant cells in cutaneous granulomas and may play a critical role in disease pathogenesis.
