Glucose Metabolism in Cancer
Glucose Metabolism in Cancer
复制标题
DOI：
10.1007/978-3-319-77736-8_1
复制
发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Le, Anne
中科院分区：
文献类型：
--
作者：
Bose, Sminu;Le, Anne
奥托·华伯格在1924年观察到了一种奇怪的现象，在不知不觉中为癌症新陈代谢领域奠定了基础。虽然他的同龄人假设肿瘤细胞从蛋白质分解和脂肪分解中获得了不受控制的复制所需的能量，但Warburg却发现它们迅速消耗葡萄糖，将其转化为乳酸[1]。这一发现的意义，后来被称为沃堡效应，当时没有被更大的科学界注意到。癌症新陈代谢领域休眠了近一个世纪，等待分子生物学和遗传学的进展，这将为新的癌症疗法打开大门。
Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate [1]. The significance of this finding, later termed the Warburg effect, went unnoticed by the larger scientific community at that time. The field of cancer metabolism lay dormant for almost a century awaiting advances in molecular biology and genetics which would later open the doors to new cancer therapies.