Evolution of Shape by Multiple Regulatory Changes to a Growth Gene
Evolution of Shape by Multiple Regulatory Changes to a Growth Gene
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DOI：
10.1126/science.1215193
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发表时间：
2012-02-24
期刊：
影响因子：
56.9
通讯作者：
Werren, John H.
中科院分区：
文献类型：
--
作者：
Loehlin, David W.;Werren, John H.
导致物种间形态差异的遗传变化在很大程度上尚未确定。这些变化可能涉及与理解进化、发育和疾病相关的生长修饰。我们确定了一个基因，诱导男性特定的翅膀大小和形状之间的差异纳苏尼亚黄蜂物种。精细定位和原位杂交显示，在至少三个区域（两个严格的非编码序列）周围的基因unpaired-like（upd-like）的变化引起的空间和时间的变化，upd-like在发展中的翅膀和相应的翅膀宽度的变化表达。upd样显示同源性的果蝇未配对基因，一个充分研究的信号蛋白，调节细胞增殖和分化。我们的研究结果表明，多种变化的upd-like的调节参与物种之间的形态和性别特异性差异的微进化。
The genetic changes responsible for morphological differences between species are largely unidentified. Such changes can involve modifications of growth that are relevant to understanding evolution, development, and disease. We identified a gene that induces male-specific wing size and shape differences between Nasonia wasp species. Fine-scale mapping and in situ hybridization reveal that changes in at least three regions (two strictly in noncoding sequence) around the gene unpaired-like (upd-like) cause changes in spatial and temporal expression of upd-like in the developing wing and corresponding changes in wing width. Upd-like shows homology to the Drosophila unpaired gene, a well-studied signaling protein that regulates cell proliferation and differentiation. Our results indicate how multiple changes in the regulation of upd-like are involved in microevolution of morphological and sex-specific differences between species.