Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHREaEuro
Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHREaEuro
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DOI：
10.1093/humrep/dew151
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发表时间：
2016-08-01
影响因子：
6.1
通讯作者：
Baranowski, Richard
中科院分区：
文献类型：
--
作者：
Calhaz-Jorge, C.;de Geyter, C.;Baranowski, Richard
第16期欧洲体外受精监测（EIM）报告介绍了2012年欧洲启动的涉及辅助生殖技术（ART）和宫腔内人工授精（IUI）的治疗数据：与前几年相比是否有任何变化？尽管报告数据的国家数量有所波动，但抗逆转录病毒治疗周期总数继续逐年增加，2012年的妊娠率与2011年报告的妊娠率相比保持稳定，多个胚胎（3+）移植数量和多胎分娩率低于以往任何时候。欧洲的ART数据已收集并报告在15份手稿中，发表在Human Reproduction.Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology（ESHRE）。2012年1月1日至12月31日周期的数据是从现有的国家登记册收集的，或在自愿的基础上通过个人信息收集的。（与2011年相比增加1），1111家诊所报告了640144个治疗周期，包括139978个IVF周期，312600个ICSI周期，其中冷冻胚胎移植（FER）139 558例，卵子捐献（艾德）33 605例，体外成熟421例，植入前遗传学诊断/植入前遗传学筛查8433例，冷冻卵母细胞移植（FOR）5549例。来自24个国家的1126个IUI实验室报告了使用丈夫/伴侣精液（IUI-H）和供体精液（IUI-D）进行宫内授精的欧洲数据。在所有诊所都向其抗逆转录病毒治疗登记处报告的18个国家中，在约2.95亿居民中共进行了369 081个抗逆转录病毒治疗周期，相当于每百万居民1252个周期（范围为每百万居民325-2732个周期）。对于所有IVF周期，每次抽吸和每次转移的临床PR稳定，分别为29.4（2011年为29.1%）和33.8%（2011年为33.2%）。对于ICSI，相应的比率也保持稳定，分别为27.8%（2011年为27.9%）和32.3%（2011年为31.8%）。在FER循环中，每次解冻/升温的PR增加至23.1%（2011年为21.3%）。在艾德周期中，每次新鲜转移的PR增加到48.4%（2011年为45.8%），每次解冻转移的PR增加到35.9%（2011年为33.6%），而在FOR后转移的PR为45.1%。IUI后的分娩率保持稳定，IUI-H后为8.5%（2011年为8.3%），IUI-D后为12.0%（2011年为12.2%）。在IVF和ICSI周期中，分别有30.2%、55.4%、13.3%和1.1%的周期移植了1、2、3和4+胚胎。IVF和ICSI后单胎、双胎和三胎分娩的比例（加在一起）分别为82.1%、17.3%和0.6%，总多胎分娩率为17.9%，而2011年为19.2%，2010年为20.6%。在FER周期中，多胎分娩率为12.5%（双胎12.2%，三胎0.3%）。与IUI周期相关的双胞胎和三胞胎分娩率分别为9.0%/0.4%和7.2%/0.5%.The报告方法因国家而异，一些国家的登记无法提供一些相关数据，如启动周期和分娩。只要数据是不完整的，并通过不同的收集方法产生的，结果应谨慎解释。第16次ESHRE关于ART的报告显示，欧洲的治疗周期数持续扩大，2012年报告的治疗周期数超过64万个，对许多国家出生率的贡献越来越大。然而，仍然明显需要改进国家登记册并使之标准化，以及建立验证方法。没有利益冲突。
The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years?Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before.Since 1997, ART data in Europe have been collected and re-ported in 15 manuscripts, published in Human Reproduction.Retrospective data collection of European ART data by the EIM Consortium for the European Society of Human Reproduction and Embryology (ESHRE). Data for cycles between 1 January and 31 December 2012 were collected from National Registers, when existing, or on a voluntary basis by personal information.From 34 countries (+1 compared with 2011), 1111 clinics reported 640 144 treatment cycles including 139 978 of IVF, 312 600 of ICSI, 139 558 of frozen embryo replacement (FER), 33 605 of egg donation (ED), 421 of in vitro maturation, 8433 of preimplantation genetic diagnosis/preimplantation genetic screening and 5549 of frozen oocyte replacements (FOR). European data on intrauterine insemination using husband/partner's semen (IUI-H) and donor semen (IUI-D) were reported from 1126 IUI labs in 24 countries. A total of 175 028 IUI-H and 43 497 IUI-D cycles were included.In 18 countries where all clinics reported to their ART register, a total of 369 081 ART cycles were performed in a population of around 295 million inhabitants, corresponding to 1252 cycles per million inhabitants (range 325-2732 cycles per million inhabitants). For all IVF cycles, the clinical PRs per aspiration and per transfer were stable with 29.4 (29.1% in 2011) and 33.8% (33.2% in 2011), respectively. For ICSI, the corresponding rates also were stable with 27.8 (27.9% in 2011) and 32.3% (31.8% in 2011). In FER cycles, the PR per thawing/warming increased to 23.1% (21.3% in 2011). In ED cycles, the PR per fresh transfer increased to 48.4% (45.8% in 2011) and to 35.9% (33.6% in 2011) per thawed transfer, while it was 45.1% for transfers after FOR. The delivery rate after IUI remained stable, at 8.5% (8.3% in 2011) after IUI-H and 12.0% (12.2% in 2011) after IUI-D. In IVF and ICSI cycles, 1, 2, 3 and 4+ embryos were transferred in 30.2, 55.4, 13.3 and 1.1% of the cycles, respectively. The proportions of singleton, twin and triplet deliveries after IVF and ICSI (added together) were 82.1, 17.3 and 0.6%, respectively, resulting in a total multiple delivery rate of 17.9% compared with 19.2% in 2011 and 20.6% in 2010. In FER cycles, the multiple delivery rate was 12.5% (12.2% twins and 0.3% triplets). Twin and triplet delivery rates associated with IUI cycles were 9.0%/0.4% and 7.2%/0.5%, following treatment with husband and donor semen, respectively.The method of reporting varies among countries, and registers from a number of countries have been unable to provide some of the relevant data such as initiated cycles and deliveries. As long as data are incomplete and generated through different methods of collection, results should be interpreted with caution.The 16th ESHRE report on ART shows a continuing expansion of the number of treatment cycles in Europe, with more than 640 000 cycles reported in 2012 with an increasing contribution to birthrate in many countries. However, the need to improve and standardize the national registries, and to establish validation methodologies remains manifest.The study has no external funding; all costs are covered by ESHRE. There are no competing interests.