Plasma and cerebrospinal fluid G72 protein levels in schizophrenia and major depressive disorder
Plasma and cerebrospinal fluid G72 protein levels in schizophrenia and major depressive disorder
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DOI：
10.1016/j.psychres.2017.04.060
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发表时间：
2017-08-01
影响因子：
11.3
通讯作者：
Kunugi, Hiroshi
中科院分区：
文献类型：
--
作者：
Ishiwata, Sayuri;Hattori, Kotaro;Kunugi, Hiroshi
G72是D-氨基酸氧化酶的调节剂，D-氨基酸氧化酶是一种降解n-丝氨酸的酶，n-丝氨酸是一种在谷氨酸神经传递中发挥关键作用的氨基酸，它与精神疾病有关。本研究旨在探讨精神分裂症或抑郁症患者血浆或脑脊液G72蛋白水平是否发生改变，以及G72蛋白水平与疾病严重程度之间是否存在相关性。最初，纳入了年龄、性别和种族匹配的27名精神分裂症患者、26名MDD患者和27名健康对照。精神分裂症和MDD患者的血浆或脑脊液G72水平与对照组相比无显著差异。虽然我们发现血浆G72水平与阳性和阴性症状量表(PANSS)上的阳性症状评分之间存在显著的正相关，但在第二项研究(40名精神分裂症患者)中没有重复这一点。脑脊液G72水平与PANSS评分无显著相关性。在MDD患者中，血浆和脑脊液G72水平与抑郁严重程度均无明显相关性。由于我们患者的严重程度相对较轻，有必要对大量受试者进行进一步调查，包括非药物患者、年轻患者和受影响较严重的患者。
G72 is a modulator of D-amino acid oxidase, the enzyme that degrades n-serine, an amino acid that plays a critical role in glutamate neurotransmission, and has been implicated in psychiatric disorders. The aim of this study was to examine whether plasma or cerebrospinal fluid (CSF) G72 protein levels were altered in either schizophrenia or major depressive disorder (MDD) and whether any correlation between G72 levels and disease severity existed. Initially, 27 schizophrenic patients, 26 MDD patients, and 27 healthy controls matched for age, sex, and ethnicity were enrolled. Compared to those of controls, plasma or CSF G72 levels were not significantly different in patients with schizophrenia or MDD. Although we found a significant positive correlation between plasma G72 levels and a positive symptoms score on the positive and negative syndrome scale (PANSS), this was not replicated in the second study (40 schizophrenic patients). CSF G72 levels showed no significant correlation with PANSS scores. In MDD, neither plasma nor CSF G72 levels correlated significantly with depression severity. Since severity of our patients were relatively mild, further investigations in a large number of subjects including drug-free patients, younger patients, and more severely affected patients are warranted.