Developmental mechanism of the tarsus in insect legs
Developmental mechanism of the tarsus in insect legs
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DOI：
10.1016/j.cois.2016.11.002
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发表时间：
2017-02-01
影响因子：
5.3
通讯作者：
Kojima, Tetsuya
中科院分区：
文献类型：
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作者：
Kojima, Tetsuya
昆虫具有巨大的形态多样性，一直是形态进化研究的对象。在腿中，跗骨在子节（跗骨节）的数量和它们的比例上特别可变，不像其他腿节。最近对黑腹果蝇的研究揭示了跗骨发育的细节：通过整合调控网络及其生长对跗骨区域进行区域化，通过严格调控Notch活性确定每个节段中的关节形成区域，通过调控RhoGTPases调节剂和局部细胞死亡改变组织形态，最后，跗骨节之间球窝关节的形态发生机制。跗骨发育的大量知识使其成为研究形态进化和多样化机制的合适模型。
Insects show a tremendous morphological variety and have been a subject of studying morphological evolution. In legs, the tarsus is especially variable in the number of subsegments (tarsal segments) and their proportion unlike other leg segments. Recent studies in Drosophila melanogaster have revealed details of the tarsal development: regionalization of the tarsal region through integration of regulatory network and its growth, determination of the joint-forming region in each segment through strict regulation of Notch activity, changes in tissue morphology through regulation of RhoGTPases regulators and localized cell death, and finally, the morphogenetic mechanism of the ball-and-socket joint between tarsal segments. The substantial knowledge of the tarsal development makes it a suitable model for studying mechanisms of morphological evolution and diversification.