Solvent Dependence of Tautomeric Equilibria of 1‐(o‐Substituted Phenyl)Barbituric and ‐2‐Thiobarbituric Acid Derivatives
Solvent Dependence of Tautomeric Equilibria of 1‐(o‐Substituted Phenyl)Barbituric and ‐2‐Thiobarbituric Acid Derivatives
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DOI：
10.1081/sl-200037606
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发表时间：
2004-12
影响因子：
1.7
通讯作者：
S. Oğuz;I. Dogan
中科院分区：
文献类型：
--
作者：
S. Oğuz;I. Dogan
摘要 通过1H和13C NMR观察化合物在不同溶剂中的行为，研究了1-（邻位取代苯基）巴比妥酸和-2-硫代巴比妥酸衍生物的烯醇化倾向。已经发现，在极性溶剂中观察到的硫代巴比妥酸衍生物的烯醇化倾向大于巴比妥酸衍生物的烯醇化倾向。计算了 DMSO 和 DMF 中硫代巴比妥酸衍生物的酮-烯醇互变异构体的比率。
Abstract The enolisation tendencies of 1‐(o‐substituted phenyl)barbituric and ‐2‐thiobarbituric acid derivatives have been studied by observing the behaviour of the compounds in different solvents by 1H and 13C NMR. It has been found that the enolisation tendencies of the thiobarbituric acid derivatives observed in polar solvents are greater than those of the barbituric acid derivatives. The ratio of keto–enol tautomers of thiobarbituric acid derivatives in DMSO and in DMF has been calculated.