The interleukin-1 genotype as a severity factor in adult periodontal disease
The interleukin-1 genotype as a severity factor in adult periodontal disease
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DOI：
10.1111/j.1600-051x.1997.tb01187.x
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发表时间：
1997-01-01
影响因子：
6.7
通讯作者：
Duff, GW
中科院分区：
文献类型：
--
作者：
Kornman, KS;Crane, A;Duff, GW
虽然特定的细菌、牙菌斑和年龄与牙周病有关，但目前还没有可靠的牙周炎严重程度的预测因素。双胞胎的研究表明遗传因素对牙周炎的发病机制有贡献，但以前试图确定遗传标记一直不成功。促炎细胞因子白细胞介素-1（IL-1）和肿瘤坏死因子α（TNF α）是宿主对微生物感染反应的关键调节因子。IL-1也是细胞外基质骨代谢和骨吸收的主要调节剂。我们报告了一个特定的基因型的多态性IL-1基因簇，与牙周炎的严重程度在非吸烟者，并区分严修与轻度牙周炎（优势比18.9，年龄40-60岁）。在功能上，特定的牙周炎相关的IL-1基因型包括与高水平的IL-1产生相关的IL-1B基因的变体。在吸烟者中，严重疾病与基因型无关。在本研究中，86.0%的重度牙周炎患者由吸烟或IL-1基因型引起。这项研究表明，与IL-1产生增加相关的特定遗传标记是成年人严重牙周炎易感性的一个强有力的指标。
Although specific bacteria, dental plaque, and age are associated with periodontal disease, there are currently no reliable predictors of periodontitis severity. Studies in twins have suggested a genetic contribution to the pathogenesis of periodontitis, but previous attempts to identify genetic markers have been unsuccessful. The pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF alpha) are key regulators of the host responses to microbial infection. IL-1 is also a major modulator of extracellular matrix catabolism and bone resorption. We report a specific genotype of the polymorphic IL-1 gene cluster that was associated with severity of periodontitis in non-smokers, and distinguished individuals with severe periodontitis from those with mild disease (odds ratio 18.9 for ages 40-60 years). Functionally the specific periodontitis-associated IL-1 genotype comprises a variant in the IL-1B gene that is associated with high levels of IL-1 production. In smokers severe disease was not correlated with genotype. In this study, 86.0% of the severe periodontitis patients were accounted for by either smoking or the IL-1 genotype. This study demonstrates that specific genetic markers, that have been associated with increased IL-1 production, are a strong indicator of susceptibility to severe periodontitis in adults.