Febuxostat-associated drug reaction with eosinophilia and systemic symptoms (DRESS)
Febuxostat-associated drug reaction with eosinophilia and systemic symptoms (DRESS)
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DOI：
10.1111/jcpt.12322
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发表时间：
2015-12-01
影响因子：
2
通讯作者：
Chen, C. -H.
中科院分区：
文献类型：
--
作者：
Chou, H. -Y.;Chen, C. -B.;Chen, C. -H.
已知情况和目的：非布司他被推荐作为有别嘌呤醇过敏史或携带HLA-B*5801等位基因的痛风患者的替代药物。病例总结：一名81岁男性，有痛风病史，以全身皮疹2天就诊。服用非布司他2天后，患者出现全身皮疹伴高热。实验室检查显示肝酶升高和急性肾损伤。已知和客观情况：这是第一例确诊的非布司他相关DRESS。当观察到DRESS时，应立即停用非布司他，以避免进一步的严重并发症。
What is known and objective: Febuxostat is recommended as an alternative drug for gouty patients with a history of allopurinol hypersensitivity or carrying the HLA-B*5801 allele.Case summary: An 81-year-old man with the medical history of gout presented to our clinic with generalized rashes for 2 days. After taking febuxostat for 2 days, he developed generalized skin rash with high fever. Laboratory tests showed elevated liver enzymes and acute kidney injury.What is known and objective: This is the first identified case of febuxostat-associated DRESS. Febuxostat should be withdrawn immediately when DRESS is observed to avoid further serious complications.