Radical Conjugate Addition ofAryl-Tethered β-Alkoxyacrylates: Formal Synthesisof (±)-Frenolicin B and (±)-epi-FrenolicinB
Radical Conjugate Addition ofAryl-Tethered β-Alkoxyacrylates: Formal Synthesisof (±)-Frenolicin B and (±)-epi-FrenolicinB
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DOI：
10.1055/s-0029-1217118
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发表时间：
2010-02
期刊：
影响因子：
--
通讯作者：
C. Donner
中科院分区：
文献类型：
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作者：
C. Donner
在苯并吡喃-γ-内酯-融合三环体系的制备中，证明了芳系o -锡基基自由基与β-烷氧基丙烯酸酯的共轭加成。然后将该方法应用于激酶抑制剂（±）-frenolicin B和（±）-epi-frenolicin B的立体发散形式合成。
The radical conjugate addition of aromatic-tethered O-stannyl ketyl radicals to β-alkoxyacrylates is demonstrated for the preparation of benzopyran-γ-lactone-fused tricyclic systems. This method is then applied to the stereodivergent formal synthesis of the kinase inhibitor (±)-frenolicin B and (±)-epi-frenolicin B.