Cadherin-11 in synovial lining formation and pathology in arthritis
Cadherin-11 in synovial lining formation and pathology in arthritis
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DOI：
10.1126/science.1137306
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发表时间：
2007-02-16
期刊：
影响因子：
56.9
通讯作者：
Brenner, Michael B.
中科院分区：
文献类型：
--
作者：
Lee, David M.;Kiener, Hans P.;Brenner, Michael B.
正常的滑膜在关节边缘形成一层膜，为软骨提供润滑和营养。在类风湿性关节炎中，滑膜是炎症的部位，并且它参与破坏软骨和骨的有组织的组织反应。我们确定钙粘蛋白-11对滑膜的发育至关重要。钙粘蛋白-11缺陷的小鼠具有发育不良的滑膜衬里，显示出对炎症的紊乱的滑膜反应，并且对炎性关节炎具有抗性。钙粘蛋白-11治疗预防和减少小鼠模型中的关节炎。因此，滑膜钙粘蛋白-11决定了滑膜细胞在炎症性关节炎中的促炎和破坏性组织反应中的行为。
The normal synovium forms a membrane at the edges of joints and provides lubrication and nutrients for the cartilage. In rheumatoid arthritis, the synovium is the site of inflammation, and it participates in an organized tissue response that damages cartilage and bone. We identified cadherin-11 as essential for the development of the synovium. Cadherin-11-deficient mice have a hypoplastic synovial lining, display a disorganized synovial reaction to inflammation, and are resistant to inflammatory arthritis. Cadherin-11 therapeutics prevent and reduce arthritis in mouse models. Thus, synovial cadherin-11 determines the behavior of synovial cells in their proinflammatory and destructive tissue response in inflammatory arthritis.