Nam7 Hydroxylase Is Responsible for the Formation of the Naphthalenic Ring in the Biosynthesis of Neoansamycins
Nam7 Hydroxylase Is Responsible for the Formation of the Naphthalenic Ring in the Biosynthesis of Neoansamycins
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Nam7 羟化酶负责新安沙霉素生物合成中萘环的形成
DOI：
10.1021/acs.orglett.7b01083
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发表时间：
2017
期刊：
影响因子：
5.2
通讯作者：
Shen Yuemao
中科院分区：
文献类型：
--
作者：
Zhang Juanli;Li Shanren;Wu Xingkang;Guo Zhixing;Lu Chunhua;Shen Yuemao
从菌株SR 201 nam 1 OE Δ nam 7中分离得到10个新的苯型安莎霉素，即5，10-开环新安莎霉素A-J（1-10）。这些是新安莎霉素的苯对应物，这为推定的羟化酶Nam 7参与新安莎霉素生物合成中萘环的形成提供了直接证据，并首次将苯和萘安莎霉素联系起来。
Ten new benzenic ansamycins, 5,10-seco-neoansamycins A–J (1–10), were isolated from thenam7-disrupted mutant strain SR201nam1OEΔnam7. These are the benzenic counterparts of the neoansamycins, which provide direct evidence that the putative hydroxylase Nam7 is involved in the formation of naphthalenic ring in neoansamycin biosynthesis and connect benzenic and naphthalenic ansamycins for the first time.