INTERLEUKIN-2 RECEPTOR-ALPHA CHAIN REGULATES THE SIZE AND CONTENT OF THE PERIPHERAL LYMPHOID COMPARTMENT
INTERLEUKIN-2 RECEPTOR-ALPHA CHAIN REGULATES THE SIZE AND CONTENT OF THE PERIPHERAL LYMPHOID COMPARTMENT
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DOI：
10.1016/1074-7613(95)90180-9
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发表时间：
1995-10-01
期刊：
影响因子：
32.4
通讯作者：
ALT, FW
中科院分区：
文献类型：
--
作者：
WILLERFORD, DM;CHEN, JZ;ALT, FW
白介素 2 受体 α 链 (IL-2R α) 表达发生在早期 T 和 B 淋巴细胞发育的特定阶段，并在成熟淋巴细胞激活后被诱导。缺乏 IL-2R α 的幼鼠具有正常的 T 细胞和 B 细胞发育表型。然而，成年后，这些小鼠的外周淋巴器官会出现大量肿大，这与多克隆 T 和 B 细胞扩增有关，对于 T 细胞来说，这与体内激活受损诱导的细胞死亡有关。老年 IL-2R α 缺陷小鼠也会出现自身免疫性疾病，包括溶血性贫血和炎症性鲍病。因此，IL-2R α对于调节外周淋巴室的大小和内容至关重要，可能是通过影响淋巴细胞激活后克隆扩张和细胞死亡之间的平衡来实现的。
Interleukin-2 receptor alpha chain (IL-2R alpha) expression occurs at specific stages of early T and B lymphocyte development and is induced upon activation of mature lymphocytes. Young mice that lack IL-2R alpha have phenotypically normal development of T and B cells. However, as adults, these mice develop massive enlargement of peripheral lymphoid organs associated with polyclonal T and B cell expansion, which, for T cells, is correlated with impaired activation-induced cell death in vivo. Older IL-2R alpha-deficient mice also develop autoimmune disorders, including hemolytic anemia and inflammatory bower disease. Thus, IL-2R alpha is essential for regulation of both the size and content of the peripheral lymphoid compartment, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation.