THE DISTRIBUTION OF 5-HT1D AND 5-HT1E BINDING-SITES IN HUMAN BRAIN
THE DISTRIBUTION OF 5-HT1D AND 5-HT1E BINDING-SITES IN HUMAN BRAIN
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DOI：
10.1016/0014-2999(92)90473-h
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发表时间：
1992-11-03
影响因子：
5
通讯作者：
HORTON, RW
中科院分区：
文献类型：
--
作者：
LOWTHER, S;DEPAERMENTIER, F;HORTON, RW
测定了人额叶皮质、海马、杏仁核、苍白球、尾状核和壳核的5-HT1、5-HT1D和5-HT1E结合部位。5-HT1亚型以5-HT1D/1E结合位点为主(占总5-HT1位点的66-95%)，海马区除外(占总5-HT1位点的38%)。苍白球含有最高密度和最高比例的5-HT1D位点(占总5-HT1位点的74%)。其他脑区的5-HT1D位点占总5-HT1位点的19-27%。5-HT1E的密度和比例以尾状核(72%)和壳核(%)最高，而在海马区密度和比例最低(16%)。
Total 5-HT1, 5-HT1D and 5-HT1E binding sites were measured in homogenates of human frontal cortex, hippocampus, amygdala, globus pallidus, caudate and putamen. Combined 5-HT1D/1E sites were the predominant 5-HT1 subtype (66-95% of total 5-HT1 sites) in all regions except hippocampus (38% of total 5-HT, sites). Globus pallidus contained the highest density and the highest proportion of 5-HT1D sites (74% of total 5-HT1 sites). 5-HT1D sites in the other brain areas accounted for 19-27% of the total 5-HT1 sites. The highest densities and the highest proportions of 5-HT1E sites were in caudate (72%) and putamen (64%) and the lowest density and lowest proportion in hippocampus (16%).