Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: An Updated Consensus Approach from the Transatlantic Australasian RPS Working Group.
Management of Primary Retroperitoneal Sarcoma (RPS) in the Adult: An Updated Consensus Approach from the Transatlantic Australasian RPS Working Group.
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成人中主要腹膜后肉瘤（RPS）的管理：跨大西洋澳大利亚RPS工作组的更新共识方法。
DOI：
10.1245/s10434-021-09654-z
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发表时间：
2021-11
影响因子：
3.7
通讯作者：
Gronchi, Alessandro
中科院分区：
文献类型：
--
作者：
Swallow, Carol J.;Strauss, Dirk C.;Bonvalot, Sylvie;Rutkowski, Piotr;Desai, Anant;Gladdy, Rebecca A.;Gonzalez, Ricardo;Gyorki, David E.;Fairweather, Mark;van Houdt, Winan J.;Stoeckle, Eberhard;Park, Jae Berm;Albertsmeier, Markus;Nessim, Carolyn;Cardona, Kenneth;Fiore, Marco;Hayes, Andrew;Tzanis, Dimitri;Skoczylas, Jacek;Ford, Samuel J.;Ng, Deanna;Mullinax, John E.;Snow, Hayden;Haas, Rick L.;Callegaro, Dario;Smith, Myles J.;Bouhadiba, Toufik;Stacchiotti, Silvia;Jones, Robin L.;DeLaney, Thomas;Roland, Christina L.;Raut, Chandrajit P.;Gronchi, Alessandro
腹膜后软组织肉瘤是一组罕见的间质来源的肿瘤，包括几个明确的组织学亚型。2015年，跨大西洋澳大拉西亚RPS工作组（TARPSWG）发表了关于原发性腹膜后肉瘤（RPS）最佳管理的共识建议。自那时以来，通过国际合作，产生了新的证据和知识，需要更新共识文件。本研究的主要目的是批判性地评估目前的证据，并制定一个最新的共识文件，对这些困难的肿瘤的方法。所得文件适用于非内脏来源的原发性RPS，排除标准如前所述。对相关文献进行了评价，并咨询了一个国际专家组，以制定关于原发性RPS最佳管理的共识声明。每项新的/更新的建议都有证据等级和建议等级。从诊断到随访，均考虑原发性RPS的管理。这种罕见而复杂的恶性肿瘤最好由专业转诊中心的经验丰富的多学科团队进行管理。治愈的最佳机会是在初次就诊时，应根据本文中所有作者一致同意的29项共识声明制定个性化的管理计划。只要有可能，应将患者纳入前瞻性试验和研究。持续的国际合作对于扩大现有知识并进一步改善RPS患者的结局至关重要。此外，强烈鼓励前瞻性数据收集和参与多机构试验。
Retroperitoneal soft tissue sarcomas comprise a heterogeneous group of rare tumors of mesenchymal origin that include several well-defined histologic subtypes. In 2015, the Transatlantic Australasian RPS Working Group (TARPSWG) published consensus recommendations for the best management of primary retroperitoneal sarcoma (RPS). Since then, through international collaboration, new evidence and knowledge have been generated, creating the need for an updated consensus document. The primary aim of this study was to critically evaluate the current evidence and develop an up-to-date consensus document on the approach to these difficult tumors. The resulting document applies to primary RPS that is non-visceral in origin, with exclusion criteria as previously described. The relevant literature was evaluated and an international group of experts consulted to formulate consensus statements regarding the best management of primary RPS. A level of evidence and grade of recommendation were attributed to each new/updated recommendation. Management of primary RPS was considered from diagnosis to follow-up. This rare and complex malignancy is best managed by an experienced multidisciplinary team in a specialized referral center. The best chance of cure is at the time of primary presentation, and an individualized management plan should be made based on the 29 consensus statements included in this article, which were agreed upon by all of the authors. Whenever possible, patients should be enrolled in prospective trials and studies. Ongoing international collaboration is critical to expand upon current knowledge and further improve outcomes of patients with RPS. In addition, prospective data collection and participation in multi-institution trials are strongly encouraged.
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影响因子：
9
作者：
Anaja, Daniel A.;Lahat, Guy;Pollock, Raphael E.
通讯作者：
Pollock, Raphael E.
影响因子：
5.9
作者：
Fendler, Wolfgang P.;Chalkidis, Rebecca P.;Hacker, Marcus
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Hacker, Marcus
影响因子：
51.1
作者：
Bonvolot, Sylvie;Gronchi, Alessandro;Haas, Rick L.
通讯作者：
Haas, Rick L.
影响因子：
3.7
作者：
Bonvalot, S.;Gaignard, E.;Blay, J. Y.
通讯作者：
Blay, J. Y.
影响因子：
3.7
作者：
Canter RJ;Qin LX;Ferrone CR;Maki RG;Singer S;Brennan MF
通讯作者：
Brennan MF