LOCATIONAL AGREEMENT OF NEAR-INFRARED AUTOFLUORESCENCE WITH CHOROIDAL VASCULAR HYPERPERMEABILITY IN CENTRAL SEROUS CHORIORETINOPATHY
LOCATIONAL AGREEMENT OF NEAR-INFRARED AUTOFLUORESCENCE WITH CHOROIDAL VASCULAR HYPERPERMEABILITY IN CENTRAL SEROUS CHORIORETINOPATHY
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DOI：
10.1097/iae.0000000000003593
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发表时间：
2022-11-01
影响因子：
3.3
通讯作者：
Obata，Ryo
中科院分区：
文献类型：
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作者：
Azuma，Keiko;Nomura，Yoko;Obata，Ryo
目的：利用多模态成像来表征脉络膜血管通透性过高（CVH）（中心性浆液性脉络膜视网膜病变的标志）眼睛的检查结果，并研究这些检查结果与 CVH 之间的位置一致性。方法：在任一只眼睛患有中心性浆液性脉络膜视网膜病变的患者中，纳入使用吲哚菁绿血管造影术确定的 CVH 且无渗出性改变的眼睛。所有眼睛均使用眼底镜、荧光素血管造影、谱域光学相干断层扫描和短波长或近红外自发荧光（SWAF 或 NIRAF）进行检查。针对每种方式评估了 CVH 和影像学结果之间的位置一致性。计算它们如何重叠的相对指数作为重叠指数。还评估了二值化图像，特别是 NIRAF。 结果：本研究包括 28 名患者 33 只眼睛的 69 个 CVH 部位。 PacHydrusen 在 36% 的 CVH 位点中被检测到。荧光素血管造影显示 39% 的 CVH 部位存在高荧光区域。光学相干断层扫描结果识别出 65% 的 CVH 位点，但重叠指数为 5%。短波长或近红外自发荧光成像识别出 89% 的 CVH 位点，但它们表现出可变的自发荧光。 NIRAF 成像显示所有 CVH 部位均存在低自发荧光现象。二值化后，在所有 CVH 位点均观察到近红外自发荧光暗点。二值化前后的重叠指数分别为78%和98%。近红外自发荧光暗点区域与 CVH 区域吻合良好（组内相关系数，0.987 [95% 置信区间，0.952–0.995]）。结论：NIRAF 成像显示的低自发荧光结果，特别是在二值化处理后，与 CVH 位点吻合良好。这些多模态成像结果可能有助于研究中心性浆液性脉络膜视网膜病变患者 CVH 的解剖或位置特征。
Purpose:To characterize the findings of eyes with choroidal vascular hyperpermeability (CVH), a hallmark of central serous chorioretinopathy, using multimodal imaging and investigate the locational agreement between these findings and CVH.Methods:Among patients with central serous chorioretinopathy in either eye, eyes with CVH identified using indocyanine green angiography without exudative changes were included. All eyes were examined using funduscopy, fluorescein angiography, spectral-domain optical coherence tomography, and short-wavelength or near-infrared autofluorescence (SWAF or NIRAF). The locational agreement between CVH and imaging findings was evaluated for each modality. The relative index on how they overlapped was calculated as the overlapping index. Binarized images, particularly for NIRAF, were also evaluated.Results:This study included 69 CVH sites in 33 eyes of 28 patients. Pachydrusen was detected in 36% of CVH sites. Fluorescein angiography revealed hyperfluorescent areas in 39% of CVH sites. Optical coherence tomography findings identified 65% of CVH sites, but the overlapping index was 5%. Short-wavelength or near-infrared autofluorescence imaging identified 89% of CVH sites, but they exhibited variable autofluorescence. NIRAF imaging revealed hypoautofluorescence findings in all CVH sites. When binarized, near-infrared autofluorescent dark dots were observed in all CVH sites. Overlapping indices before and after binarization were 78% and 98%, respectively. The near-infrared autofluorescent dark dots area corresponded well with that of CVH (intraclass correlation coefficient, 0.987 [95% confidence interval, 0.952–0.995]).Conclusion:Hypoautofluorescent findings revealed on NIRAF imaging, especially after binarization processing, corresponded well with CVH sites. These multimodal imaging results may help investigate the anatomical or locational characteristics of CVH in patients with central serous chorioretinopathy.