AMIODARONE KERATOPATHY - CORRELATION TO DOSAGE AND DURATION
AMIODARONE KERATOPATHY - CORRELATION TO DOSAGE AND DURATION
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DOI：
10.1001/archopht.1982.01030030603011
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
CAPPAERT, WE
中科院分区：
文献类型：
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作者：
KAPLAN, LJ;CAPPAERT, WE
盐酸胺碘酮是一种苯并呋喃衍生物，用于治疗心律失常，已知会引起轮生上皮角膜病变，分为3个阶段。每天接受低剂量 100-200 毫克胺碘酮的患者，无论治疗持续时间或摄入的物质总量如何，都可以保持透明的角膜或仅显示第 1 阶段的变化。接受 400-1400 毫克/天较高剂量的患者会出现第 2 阶段和第 3 阶段的变化，具体取决于治疗持续时间。即使剂量减少，这种角膜病变也会进展；一旦停止用药，就会完全消退。
Amiodarone hydrochloride, a benzofurane derivative used for the treatment of cardiac arrhythmias, is known to cause a verticillate epithelial keratopathy, which was classified into 3 stages. Patients receiving low dosages of 100-200 mg of amiodarone daily retain clear corneas or show stage 1 changes only, regardless of duration of treatment or total amount of substance ingested. Patients receiving higher dosages of 400-1400 mg/day show stage 2 and 3 changes, depending on duration of treatment. This keratopathy progresses, even with reduced dosage; complete regression occurs once administration of medication is discontinued.