CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS
CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS
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DOI：
10.1038/353521a0
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发表时间：
1991-10-10
期刊：
影响因子：
64.8
通讯作者：
LATHROP, GM
中科院分区：
文献类型：
--
作者：
HILBERT, P;LINDPAINTNER, K;LATHROP, GM
自发性高血压大鼠和易中风的自发性高血压大鼠是研究人类高血压的有用模型。 在这些菌株中，高血压是一种多基因性状，其中常染色体和性连锁基因都可以影响血压1-7。 在易卒中的自发性高血压大鼠和血压正常的对照品系Wistar-Kyoto之间的杂交中进行的连锁研究已经导致了两个基因BP/SP-1和BP/SP-2的定位，这两个基因对F2群体中的血压变化有显著贡献。 BP/SP-1和BP/SP-2分别定位于大鼠第10和X染色体。 人类和大鼠遗传图谱的比较表明，BP/SP-1可以驻留在人类染色体17 q上的一个区域，该区域还包含血管紧张素I转换酶基因（ACE）8。 这编码一个关键酶的肾素-血管紧张素系统9，因此是一个候选基因在原发性高血压。 ACE的大鼠微卫星标记被定位到大鼠10号染色体内含有BP/SP-1的区域。
The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure 1-7. Linkage studies in crosses between the stroke-prone spontaneously hypertensive rat and the normotensive control strain Wistar-Kyoto have led to the localization of two genes, BP/SP-1 and BP/SP-2, that contribute significantly to blood pressure variation in the F2 population. BP/SP-1 and BP/SP-2 were assigned to rat chromosomes 10 and X, respectively. Comparison of the human and rat genetic maps indicates that BP/SP-1 could reside on human chromosome 17q in a region that also contains the angiotensin I-converting enzyme gene (ACE) 8. This encodes a key enzyme of the renin-angiotensin system 9, and is therefore a candidate gene in primary hypertension. A rat microsatellite marker of ACE was mapped to rat chromosome 10 within the region containing BP/SP-1.