Silk fibroin for vascular regeneration
Silk fibroin for vascular regeneration
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DOI：
10.1002/jemt.22532
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发表时间：
2017-03
影响因子：
2.5
通讯作者：
Danyan Wang;Haifeng Liu;Yubo Fan
中科院分区：
文献类型：
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作者：
Danyan Wang;Haifeng Liu;Yubo Fan
心血管疾病是当今世界发病率和死亡率的主要原因。由于缺乏健康的自体血管，需要更多的组织工程血管来修复或替代受损的动脉。生物材料在创造具有生物反应的活血管中起着不可或缺的作用。蚕丝蛋白具有良好的细胞相容性、适宜的生物降解性、适宜的力学性能和最小的炎症反应。此外，再生丝素溶液可以加工成各种形式的支架，如薄膜、纤维、管、多孔海绵等。这些特点使丝素蛋白成为小直径血管移植的理想材料。本文主要介绍了丝素蛋白在血管再生中的应用。简要介绍了丝素蛋白的性质，并对目前用于血管再生的主要类型丝素蛋白支架的研究现状和未来发展方向进行了综述和讨论。Microsc。科学通报，2017,38(2):391 - 391。©2015 Wiley期刊公司
Cardiovascular disease is the primary cause of morbidity and mortality in today's world. Due to the lack of healthy autologous vessels, more tissue‐engineered blood vessels are needed to repair or replace the damaged arteries. Biomaterials play an indispensable role in creating a living neovessel with biological responses. Silk fibroin produced by silkworms possesses good cytocompatibility, tailorable biodegradability, suitable mechanical properties, and minimal inflammatory reactions. In addition, regenerated silk fibroin solutions can be processed into various forms of scaffolds such as films, fibers, tubes, and porous sponges. These features make silk fibroin a promising biomaterial for small‐diameter vascular grafts. The present article focuses on the applications of silk fibroin for vascular regeneration. A brief overview of the properties of silk fibroin is provided, following which the current research status and future directions of the main types of silk fibroin scaffolds for vascular regeneration are reviewed and discussed. Microsc. Res. Tech. 80:280–290, 2017. © 2015 Wiley Periodicals, Inc.