2,000 Steps/Day Does Not Fully Protect Skeletal Muscle Health in Older Adults During Bed Rest
2,000 Steps/Day Does Not Fully Protect Skeletal Muscle Health in Older Adults During Bed Rest
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DOI：
10.1123/japa.2018-0093
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发表时间：
2019-04-01
影响因子：
1.5
通讯作者：
Paddon-Jones, Douglas
中科院分区：
文献类型：
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作者：
Arentson-Lantz, Emily;Galvan, Elfego;Paddon-Jones, Douglas
住院病人的身体活动通常限于短时间的散步。对于健康的成年人，公共卫生机构建议每周至少进行150分钟的中等强度运动。作者试图确定在没有日常生活附带活动的情况下，达到这个活动阈值是否可以在卧床休息期间保护骨骼肌健康。健康老年人（68 +/- 2岁）被随机分为7天卧床休息，（STEP, n= 7）或不（CON, n= 10） 2000步/天干预。每天进行2018 +/- 4步并不能防止瘦腿质量的损失，对有氧能力、力量或肌纤维体积也没有有益的影响。然而，胰岛素对口服葡萄糖的反应被保留。在没有日常生活附带活动的情况下，每天步行2,000步不足以完全抵消健康老年人卧床休息的分解代谢影响。
Physical activity in an inpatient setting is often limited to brief periods of walking. For healthy adults, public health agencies recommend a minimum of 150 min/week of moderate-intensity exercise. The authors sought to determine if meeting this activity threshold, in the absence of incidental activities of daily living, could protect skeletal muscle health during bed rest. Healthy older adults (68 +/- 2 years) were randomized to 7-day bed rest with (STEP, n = 7) or without (CON, n= 10) a 2,000 steps/day intervention. Performing 2018 +/- 4 steps/day did not prevent the loss of lean leg mass and had no beneficial effect on aerobic capacity, strength, or muscle fiber volume. However, the insulin response to an oral glucose challenge was preserved. Performing a block of 2,000 steps/day, in the absence of incidental activities of daily living, was insufficient to fully counter the catabolic effects of bed rest in healthy older adults.