Low temperature plasma-based sterilization: Overview and state-of-the-art
Low temperature plasma-based sterilization: Overview and state-of-the-art
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DOI：
10.1002/ppap.200400078
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发表时间：
2005-06-14
影响因子：
3.5
通讯作者：
Laroussi, M
中科院分区：
文献类型：
--
作者：
Laroussi, M
低温、高压、非平衡等离子体现在通常用于几种材料处理应用中，并且在某些情况下，在低压等离子体历史上占主导地位的领域中与低压等离子体竞争。蚀刻和沉积是这种应用的示例。在非平衡等离子体的新应用中，生物医学应用如电外科手术、生物相容性材料的表面改性和热敏医疗工具的灭菌特别令人感兴趣。在本文中，首先简要概述了最近的研究，减压等离子体为基础的灭菌/去污方法。然后对大气压非平衡等离子体对细菌细胞的影响进行了详细的综述和讨论。这包括评价灭活动力学和各种血浆试剂在灭活过程中的作用。测量的等离子体温度，紫外线发射，和各种活性物种的空气等离子体的情况下的浓度。还简要讨论了等离子体的亚致死效应，并概述了“冷”等离子体在生物医学领域的应用前景。
Low temperature, high pressure, non-equilibrium plasmas are now routinely used in several material processing applications, and in some cases are competing with low pressure plasmas in areas where these have historically been dominant. Etching and deposition are examples of such applications. Amongst the novel applications of non-equilibrium plasmas, biomedical applications such as electrosurgery, surface modification of biocompatible materials, and the sterilization of heat-sensitive medical tools are particularly interesting. In this paper, first a brief overview of recent research on reduced-pressure plasma-based sterilization/ decontamination methods is given. Then a detailed review and discussion on the effects of atmospheric pressure non-equilibrium plasmas on the cells of bacteria is presented. This includes the evaluation of the inactivation kinetics and the roles of the various plasma agents in the inactivation process. Measurements of the plasma temperature, the UV emission, and concentrations of various reactive species for the case of air plasma are presented. Plasma sub-lethal effects are also briefly discussed, and the prospects of the use of "cold" plasmas in the biomedical field are outlined.