Lipid and lipoprotein concentrations in 1604 men and women in working populations in north-west London.
Lipid and lipoprotein concentrations in 1604 men and women in working populations in north-west London.
复制标题
伦敦西北部工作人群中 1604 名男性和女性的脂质和脂蛋白浓度。
作者：
J. Slack;N. Noble;T. Meade;W. North
男女血清脂质和脂蛋白浓度随年龄而变化，所谓的“正常”限度应考虑到这一点。对伦敦西北部5个工作人群的1027名男性和577名女性的血清胆固醇、甘油三酯和磷脂浓度进行了测量，并对脂蛋白浓度进行了脂蛋白电泳和定量分析。在男性中，血清胆固醇、甘油三酯和磷脂与年龄之间的最佳拟合关系是用二次回归曲线表示的。在女性中，最佳拟合是通过线性回归给出的。白人男性的血清胆固醇和甘油三酯浓度高于黑人男性，这些差异反映在脂蛋白的分布上。白人妇女和黑人妇女的价值观没有差别。服用口服避孕药的年轻妇女的脂质浓度与未服用这些制剂的老年妇女相似。这些数据表明，采用最近一份关于预防冠状动脉疾病的报告所推荐的血清胆固醇(275-300 mg/100 ml （7-1-7-8 mmol/l）和甘油三酯(175-200 mg/100 ml （2-0- 2-3 mmol/l）的浓度作为限制，应特别注意高脂血症的管理，这可能导致只有2%的年轻男性或多达31%的老年男性被选择接受治疗。
Serum lipid and lipoprotein concentrations in men and women vary with age, and so-called "normal" limits should take account of this. Serum cholesterol, triglyceride, and phospholipid concentrations were measured in 1027 men and 577 women in five working populations in north-west London, and lipoprotein electrophoresis and quantitative analyses of lipoprotein concentrations were also performed. In men the best fit between serum cholesterol, triglycerides, and phospholipids, on the one hand, and age, on the other, was given by a curvilinear relationship expressed as a quadratic regression. In women the best fit was given by a linear regression. White men had higher serum cholesterol and triglyceride concentrations than Black men, and these differences were reflected in the distributions of the lipoproteins. There were no differences between values in White and Black women. Young women on oral contraceptives had lipid concentrations similar to those of older women not on these preparations. These data suggest that the adoption of concentrations of serum cholesterol (275-300 mg/100 ml (7-1-7-8 mmol/l) and triglycerides (175-200 mg/100 ml (2-0--2-3 mmol/l) recommended by a recent report on the prevention of coronary disease as limits above which special attention should be given to the management of hyperlipidaemia could result in as few as 2% of younger men or as many as 31% of older men being selected for treatment.