Systemic Inflammatory Markers as Prognostic Factors in Stage IIA Colorectal Cancer
Systemic Inflammatory Markers as Prognostic Factors in Stage IIA Colorectal Cancer
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DOI：
10.1002/jso.24299
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发表时间：
2016-08-01
影响因子：
2.5
通讯作者：
Park, Kyu Joo
中科院分区：
文献类型：
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作者：
Park, Byung Kwan;Park, Ji Won;Park, Kyu Joo
背景：本研究的目的是评估全身炎症标志物作为IIA期结直肠癌患者的预后因素。方法：选取2002 ~ 2010年在首尔大学医院行根治性结直肠癌切除术的患者，术后病理分期为IIA （T3N0M0）的患者1035例。系统性炎症标志物，如中性粒细胞与淋巴细胞比值（NLR）、衍生中性粒细胞与淋巴细胞比值（dNLR）、血小板与淋巴细胞比值（PLR）、预后营养指数（PNI）和血清纤维蛋白原水平，均被回顾性回顾。根据受试者工作特征（ROC）曲线分析后全身炎症指标的截止值将患者分为两组。进行生存分析以确定与无病生存期（DFS）和总生存期（OS）相关的因素。结果：年龄、美国麻醉医师协会（ASA）评分、肿瘤位置、淋巴结数量、静脉侵犯、神经周围侵犯、辅助治疗和PNI （HR = 1.534, 95% CI: 1.065 ~ 2.211, P = 0.022; HR = 1.915, 95% CI: 1.286 ~ 2.852, P = 0.001）是影响DFS和OS预后的独立显著因素。结论：PNI可作为IIA期结直肠癌的预后指标。(C) 2016 Wiley期刊公司
Background: The aim of this study was to evaluate systemic inflammatory markers as prognostic factors in patients with stage IIA colorectal cancer.Methods: Among the patients who underwent curative resection for colorectal cancer at Seoul National University Hospital between 2002 and 2010, 1,035 who were classified as postoperative pathologic stage IIA (T3N0M0) were included. Systemic inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and serum fibrinogen level, were retrospectively reviewed. The patients were divided into two groups according to the cut-off values of the systemic inflammatory markers after receiver operating characteristic (ROC) curve analysis. Survival analysis was performed to identify factors associated with disease-free survival (DFS) and overall survival (OS).Results: Age, American Society of Anesthesiologists (ASA) score, tumor location, number of harvested lymph nodes, venous invasion, perineural invasion, adjuvant treatment and PNI (HR = 1.534, 95% CI: 1.065-2.211, P = 0.022; HR = 1.915, 95% CI: 1.286-2.852, P = 0.001 for DFS and OS, respectively) were independent significant prognostic factors for both DFS and OS.Conclusions: PNI can be a prognostic marker in stage IIA colorectal cancer. (C) 2016 Wiley Periodicals, Inc.