Increasing incidence of multiple sclerosis in women in Northern Finland
Increasing incidence of multiple sclerosis in women in Northern Finland
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DOI：
10.1177/1352458510384012
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发表时间：
2011-02-01
影响因子：
5.8
通讯作者：
Remes, A. M.
中科院分区：
文献类型：
--
作者：
Krokki, O.;Bloigu, R.;Remes, A. M.
背景：多发性硬化症（MS）的地理分布意味着患病率随纬度的增加而增加。从时间上看，在过去二十年中观察到多发性硬化症发病率增加的趋势。目的：由于MS在北极圈附近地区的流行病学研究很少，我们通过一项1992-2007年的回顾性队列研究评估了MS在北Ostrobothnia的发病率和患病率。方法：在北Ostrobothnia地区（人口386,972），根据Poser标准和2001年早期McDonald标准确定临床诊断为MS的患者，按1年时间间隔计算发病率，包括总体发病率和按性别的发病率。结果：总患病率为103/10万（95% CI: 93 ~ 113），男女比为2.17。平均总发病率为6.3/100,000 （95% CI, 5.2-7.2）。由于女性发病率明显上升，发病率在16年期间呈上升趋势。结论：我们的研究结果显示，MS在北部地区的患病率很高，女性MS发病率不成比例地增加。这些最近的流行病学特征可能与环境风险因素有关，如维生素D缺乏、终生紫外线辐射低和高纬度地理位置。
Background: The geographical distribution of multiple sclerosis (MS) means that prevalence rates increase with latitude north or south of the equator. Temporally, a tendency for increased incidences of MS has been observed over the past two decades.Objectives: Since epidemiological studies of MS in areas close to the Arctic Circle are rare, we evaluated the incidence and prevalence of MS in Northern Ostrobothnia by means of a retrospective cohort study covering the period 1992-2007.Methods: Patients with a definite clinical diagnosis of MS based on the Poser criteria and the early McDonald criteria of 2001 were identified in the region of Northern Ostrobothnia (population 386,972) and the incidence was calculated at 1-year time intervals, both overall and by gender.Results: The overall prevalence was 103/100,000 (95% CI, 93-113), with a female/male ratio of 2.17. The mean overall incidence was 6.3/100,000 (95% CI, 5.2-7.2). The incidence shows a tendency to increase over the 16-year period due to a pronounced rise in the female incidence.Conclusions: Our results show a high prevalence of MS in Northern Ostrobothnia and a disproportional increase in the female MS incidence. These recent epidemiological features may be associated with environmental risk factors such as a vitamin D deficit, low life-long UV radiation and the high-latitude geographical location.