Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: Implications for the pathophysiology of mood and anxiety disorders
Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: Implications for the pathophysiology of mood and anxiety disorders
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DOI：
10.1073/pnas.93.4.1619
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发表时间：
1996-02-20
影响因子：
11.1
通讯作者：
Nemeroff, CB
中科院分区：
文献类型：
--
作者：
Coplan, JD;Andrews, MW;Nemeroff, CB
越来越多的证据表明，不良的早期经历对成年后主要精神疾病的发展起着重要作用。促肾上腺皮质激素释放因子（CRF）是一种内源性神经肽，是哺乳动物应激反应的主要生理调节剂。研究人员对幼年时期暴露在不良早期养育条件下的成年非人灵长类动物进行了研究，以确定早期应激源是否发生了CRF神经系统的长期改变。与在可预测条件下觅食的母猴相比，在不可预测条件下觅食的母猴抚养的幼猴表现出持续升高的脑脊液（CSF） CRF浓度。由于crf释放神经元的过度活跃与某些人类情感障碍和焦虑障碍的病理生理有关，因此本发现提供了一种潜在的神经生物学机制，通过该机制，早期生活压力源可能有助于成人精神病理。
There is increasing evidence for an important role of adverse early experience on the development of major psychiatric disorders in adulthood. Corticotropin-releasing factor (CRF), an endogenous neuropeptide, is the primary physiological regulator of the mammalian stress response. Grown nonhuman primates who were exposed as infants to adverse early rearing conditions were studied to determine if long-term alterations of CRF neuronal systems had occurred following the early stressor. In comparison to monkeys reared by mothers foraging under predictable conditions, infant monkeys raised by mothers foraging under unpredictable conditions exhibited persistently elevated cerebrospinal fluid (CSF) concentrations of CRF. Because hyperactivity of CRF-releasing neurons has been implicated in the pathophysiology of certain human affective and anxiety disorders, the present finding provides a potential neurobiological mechanism by which early-life stressors may contribute to adult psychopathology.