Acromegalic axial arthropathy: A clinical case-control study
Acromegalic axial arthropathy: A clinical case-control study
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DOI：
10.1210/jc.2003-031283
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发表时间：
2004-02-01
影响因子：
5.8
通讯作者：
Colao, A
中科院分区：
文献类型：
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作者：
Scarpa, R;De Brasi, D;Colao, A
关节病是肢端肥大症发病的主要原因。为了突出脊柱受累，54名活动期肢端肥大症患者(男性27名，女性27名；年龄范围21-69岁)和54名性别、年龄和体重指数匹配的健康对照组被纳入这项观察性分析性前瞻性病例对照研究。一份描述关节症状发生、持续时间和严重程度的问卷；风湿学检查，包括椎体和胸部活动度、肖伯试验、胸廓扩张和轴位放射检查；以及IGF-I、GH、胰岛素和血糖水平测量(基线和口服葡萄糖耐量试验后)被用来调查关节病的患病率，并将这些结果与激素参数相关联。中枢性关节病28例(52%)，对照组12例(22%；X(2)=8.9P=0.003)。具体而言，30例患者(56%)和10名对照组(18%)脊柱活动度降低；chi(2)=14.3；P
Arthropathy is the major cause of morbidity in acromegaly. To feature the spinal involvement, 54 patients with active acromegaly (27 men, 27 women; age range, 21-69 yr) and 54 sex-, age-, and body mass index-matched healthy controls were enrolled in this observational analytical prospective case-control study. A questionnaire to describe onset, duration, and severity of articular symptoms; rheumatological examination, including vertebral and chest mobility, Schober test, thorax expansion, and axial radiological study; and IGF-I, GH, insulin, and glucose level measurement (baseline and after an oral glucose tolerance test) was used to investigate the prevalence of arthropathy and correlate these findings with hormonal parameters. Axial arthropathy was found in 28 patients (52%) and 12 controls (22%; chi(2)=8.9; P=0.003). In detail, spinal mobility was reduced in 30 patients (56%) and 10 controls (18%; chi(2)=14.3; P