Clinical prototype of pigment and flow imaging optical coherence tomography for posterior eye investigation
Clinical prototype of pigment and flow imaging optical coherence tomography for posterior eye investigation
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DOI：
10.1364/boe.9.004372
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发表时间：
2018-09-01
影响因子：
3.4
通讯作者：
Yasuno, Yoshiaki
中科院分区：
文献类型：
--
作者：
Makita, Shuichi;Mino, Toshihiro;Yasuno, Yoshiaki
使用偏振敏感光学相干断层扫描（PS-OCT）获得的偏振（RP）的随机性的测量应用在几个应用中，RP是有吸引力的后眼成像。没有延迟的RP的添加需要对标准OCT进行最小的扩展;因此，我们开发了一种原型OCT系统，该系统具有用于RP测量的简化方案。紧凑型偏振分集接收器模块是标准OCT系统唯一需要的硬件扩展。将所有组件装入视网膜扫描头中。使用噪声校正算法计算基于OCT血管造影的偏振度均匀性和复数去相关性，该算法考虑了深度相关噪声功率。展示了活体人眼的结构、黑色素和血流分布成像。病理眼成像显示了这些对比度组合的潜在应用。(C)根据OSA开放获取出版协议的条款，2018年美国光学学会
Measurements of the randomness of polarization (RP) obtained using polarization-sensitive optical coherence tomography (PS-OCT) are applied in several applications, and RP is attractive for posterior eye imaging. The addition of RP without retardation requires a minimal extension to standard OCT; therefore, we developed a prototype OCT system with a simplified scheme for RP measurement. A compact polarization-diversity receiver module is the only required hardware extension to a standard OCT system. All components were packed into the retinal scanning head. The degree-of-polarization uniformity and complex-decorrelation based OCT angiography were calculated using noise-corrected algorithms that accounted for the depth-dependent noise power. The structure, melanin, and blood flow distribution imaging of in vivo human eyes were demonstrated. Pathological eye imaging shows potential applications for combinations of these contrasts. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement