Nano-scaled hydroxyapatite/polymer composite I.: Coating of sintered hydroxyapatite particles on poly(γ-methacryloxypropyl trimethoxysilane)-grafted silk fibroin fibers through chemical bonding
Nano-scaled hydroxyapatite/polymer composite I.: Coating of sintered hydroxyapatite particles on poly(γ-methacryloxypropyl trimethoxysilane)-grafted silk fibroin fibers through chemical bonding
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DOI：
10.1023/b:jmsm.0000010093.39298.5a
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发表时间：
2004-01-01
影响因子：
3.7
通讯作者：
Tanaka, J
中科院分区：
文献类型：
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作者：
Furuzono, T;Kishida, A;Tanaka, J
通过共价键法制备了纳米羟基磷灰石（HAp）和丝素蛋白（SF）纤维组成的无机-有机复合材料，开发了一种新型的软组织相容性生物材料。采用2-甲基丙烯氧乙基异氰酸酯（MOI）单体在SF上引入乙烯基进行化学改性，聚-甲基丙烯氧基三甲氧基硅烷（MPTS）接枝聚合SF，以及接枝后的聚合物表面与HAp纳米粒子偶联制备了该复合材料。乙烯基接枝聚合聚合物的数量受反应时间的控制。随后在真空中以120度加热2小时将纳米晶体涂覆在接枝纤维上。在此过程中，SF衬底的晶体结构没有改变。在复合材料表面的SEM观察中，发现键合的纳米晶体分离并部分聚集，并有多个晶体附着在SF纤维表面。超声处理后，HAp颗粒在SF表面的粘附比在原SF表面的粘附更强，并伴有多个晶体的分离或聚集。(C) 2004 Kluwer学术出版社。
The inorganic-organic composite consisting of a nano-scaled hydroxyapatite (HAp) and silk fibroin (SF) fibers was prepared through convalent linkage to develop a novel biomaterial for a soft-tissue-compatible material. The preparation of the composite was conducted through the three-step procedure consisting of chemical modification using 2-methacryloxyethyl isocyanate (MOI) monomer to introduce vinyl groups on SF, poly(gamma-mehtacryloxypropyl trimethoxysilane) (MPTS) graft-polymerization of SF, and coupling process between the surface of polyMPTS-grafted SF and HAp nano-particles. The amount of the graft-polymerization of polyMPTS through vinyl groups was well controlled by the reaction time. The nano-crystals were subsequently coated on the grafted fibers by heating at 120degreesC for 2 h in a vacuum. The crystalline structure of the SF substrate did not change in the procedure. In the SEM observation of the composite surface, it was found that the bonded nano-crystals were separated and partially aggregated with several crystals attached on the SF fiber surface. The HAp particles adhered more strongly on the SF surface with separation or aggregation of several crystals than on the surface of the original SF after ultrasonic treatment. (C) 2004 Kluwer Academic Publishers.