Oxidation of glutathione and cysteine in human plasma associated with smoking
Oxidation of glutathione and cysteine in human plasma associated with smoking
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DOI：
10.1016/j.freeradbiomed.2003.09.006
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发表时间：
2003-12-15
影响因子：
7.4
通讯作者：
Sternberg, P
中科院分区：
文献类型：
--
作者：
Moriarty, SE;Shah, JH;Sternberg, P
吸烟导致许多慢性和年龄相关疾病过程的发展或进展，但详细的机制仍然难以捉摸。在本研究中，我们研究了GSH/GSSG和Cys/CySS夫妇的血浆中的吸烟者和非吸烟者之间的年龄为44和85岁（n = 78非吸烟者，n = 43吸烟者）的氧化还原状态。吸烟者的Cys/CySS氧化还原（-64 +/- 16 mV）比非吸烟者的76 +/- 11 mV更氧化; p
Cigarette smoking contributes to the development or progression of numerous chronic and age-related disease processes, but detailed mechanisms remain elusive. In the present study, we examined the redox states of the GSH/GSSG and Cys/CySS couples in plasma of smokers and nonsmokers between the ages of 44 and 85 years (n = 78 nonsmokers, n = 43 smokers). The Cys/CySS redox in smokers (-64 +/- 16 mV) was more oxidized than nonsmokers 76 +/- 11 mV; p