Phenanthridine Synthesis through Iron-Catalyzed Intramolecular N-Arylation of O-Acetyl Oxime
Phenanthridine Synthesis through Iron-Catalyzed Intramolecular N-Arylation of O-Acetyl Oxime
复制标题
DOI：
10.1021/ol4020392
复制
发表时间：
2013-08-16
期刊：
影响因子：
5.2
通讯作者：
Yoshikai, Naohiko
中科院分区：
文献类型：
--
作者：
Deb, Indubhusan;Yoshikai, Naohiko
衍生自2 '-芳基苯乙酮的O-乙酰基肟在催化量的乙酰丙酮铁（III）存在下在乙酸中进行N-O键断裂/分子内N-芳基化。结合传统的交叉偶联或定向C-H芳基化反应，该反应提供了一个方便的途径取代菲啶。
O-Acetyl oximes derived from 2'-arylacetophenones undergo N-O bond cleavage/intramolecular N-arylation in the presence of a catalytic amount of iron(III) acetylacetonate in acetic acid. In combination with the conventional cross-coupling or directed C-H arylation, the reaction offers a convenient route to substituted phenanthridines.