Relation between small intestinal motor activity and transit in secretory diarrhea.
Relation between small intestinal motor activity and transit in secretory diarrhea.
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小肠运动活动与分泌性腹泻转运之间的关系。
DOI：
10.1152/ajpgi.1990.259.3.g420
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Sarna,SK
中科院分区：
文献类型：
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作者：
Cowles,VE;Sarna,SK
本研究的目的是将正常条件下进食状态和霍乱毒素诱导的分泌状态下的小肠运动活动与通过时间相关联。在控制状态下，渡越时间与平均传播距离呈强负相关，与所有收缩的频率和总持续时间呈较小程度的负相关。相比之下，传输时间与所有收缩的总振幅和面积无关。当收缩分为传播收缩和非传播收缩时，渡越时间与传播收缩的所有参数都呈极显著的负相关，而与非传播收缩的任何参数都不相关。在霍乱毒素诱导的分泌状态下也得到类似的结果。对照数据被用来开发一个数学模型，以预测运输时间从收缩参数，并使用在分泌状态下获得的数据进行验证。我们的研究结果表明，过境通过小肠在正常和分泌状态是密切相关的传播收缩的参数，但不传播收缩的参数。
Our objective in this study was to correlate small intestinal motor activity with transit time in the fed state under normal conditions and in the secretory state induced by cholera toxin. In the control state, transit time was strongly and inversely correlated with the mean distance of propagation and to a lesser degree with frequency and total duration of all contractions. By contrast, transit time was not correlated with total amplitude and area of all contractions. When contractions were separated into propagating and nonpropagating contractions, there was a highly significant inverse correlation between transit time and all parameters of propagating contractions but no relation with any parameter of nonpropagating contractions. Similar results were obtained during the secretory state induced by cholera toxin. The control data were used to develop a mathematical model to predict transit time from contractile parameters and was validated using the data obtained in the secretory state. Our findings demonstrate that transit through the small intestine in the normal and secretory states is strongly related to the parameters of propagating contractions but not to parameters of nonpropagating contractions.