Athena:: a resource for rapid visualization and systematic analysis of Arabidopsis promoter sequences
Athena:: a resource for rapid visualization and systematic analysis of Arabidopsis promoter sequences
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DOI：
10.1093/bioinformatics/bti714
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发表时间：
2005-12-15
期刊：
影响因子：
5.8
通讯作者：
Wyrick, JJ
中科院分区：
文献类型：
--
作者：
O'Connor, TR;Dyreson, C;Wyrick, JJ
为了更好地了解控制植物基因表达的调控网络，需要系统分析和可视化拟南芥启动子调控序列的工具。我们开发了Athena数据库，其中包含30067个预测的拟南芥启动子序列和105个先前表征的转录因子（TF）结合位点的共识序列。Athena提供了四种新的工具来促进启动子序列的分析：启动子可视化工具，可以快速检查多个启动子中的关键调控序列；一个TF结合位点富集工具，用于识别在用户选择的启动子子集中统计上代表性过高的TF位点；数据挖掘工具，用于快速选择包含特定TF结合位点组合的启动子序列；以及显示在选定的一组启动子序列中TF结合位点位置分布的工具。
To better understand the regulatory networks that control plant gene expression, tools are needed to systematically analyze and visualize promoter regulatory sequences in Arabidopsis thaliana. We have developed the Athena database, which contains 30 067 predicted Arabidopsis promoter sequences and consensus sequences for 105 previously characterized transcription factor (TF) binding sites. Athena provides four novel tools to facilitate the analysis of promoter sequences: a promoter visualization tool to enable the rapid inspection of key regulatory sequences in multiple promoters; a TF binding site enrichment tool to identify statistically over-represented TF sites occurring in a user-selected subset of promoters; a data-mining tool to rapidly select promoter sequences containing the specified combination of TF binding sites; and a tool to display the distribution of TF binding site positions in a selected set of promoter sequences.