Sleep disturbance in osteoarthritis: linkages with pain, disability, and depressive symptoms.
Sleep disturbance in osteoarthritis: linkages with pain, disability, and depressive symptoms.
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DOI：
10.1002/acr.22459
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发表时间：
2015-03
影响因子：
4.7
通讯作者：
Dautovich, Natalie D.
中科院分区：
文献类型：
--
作者：
Parmelee, Patricia A.;Tighe, Caitlan A.;Dautovich, Natalie D.
It is known that osteoarthritis (OA) increases risk of sleep disturbance, and that both pain and sleep problems may trigger functional disability and depression. However, studies examining all four variables simultaneously are rare. This research therefore examined cross-sectional and longitudinal associations of self-reported sleep disturbance with OA-related pain and disability, and depressive symptoms. At baseline, 367 persons with physician-diagnosed knee OA reported sleep disturbances, pain, functional limitations, and depressive symptoms. All measures were repeated a year later (N = 288). Baseline analyses examined the independent and interactive associations of sleep disturbance with pain, disability and depression, net of demographics and general health. Longitudinal analyses used baseline sleep disturbance to predict one-year change in pain, disability and depression. At baseline, sleep was independently associated with pain and depression, but not disability. The sleep-pain relationship was mediated by depressive symptoms; sleep interacted with pain to exacerbate depression among persons with high levels of pain. Baseline sleep disturbance predicted increased depression and disability, but not pain, at follow-up. These data confirm known cross-sectional relationships of sleep disturbance with pain and depression, and provide new insights on longitudinal associations among those variables. Depression appears to play a strong role in the sleep-pain linkage, particularly where pain is severe. The unique predictive role of sleep in progression of disability requires further study, but may be an important point of intervention to prevent OA-related functional decline among persons whose sleep is disrupted by OA pain.
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影响因子：
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