050. URINARY REGULATORY T-LYMPHOCYTES IDENTIFY ACTIVE RENAL ANCA-ASSOCIATED VASCULITIS
050. URINARY REGULATORY T-LYMPHOCYTES IDENTIFY ACTIVE RENAL ANCA-ASSOCIATED VASCULITIS
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050. 尿调节 T 淋巴细胞识别活动性肾 ANCA 相关血管炎
DOI：
10.1093/rheumatology/kez057.049
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发表时间：
2019
期刊：
影响因子：
5.5
通讯作者：
Sonnemann J
中科院分区：
文献类型：
--
作者：
Sonnemann J
背景：坏死性新月体肾炎(NCGN)是ANCA相关性血管炎(AAV)发病率和死亡率的主要因素。由于治疗依赖于具有潜在不良反应的细胞毒性药物，因此需要一种可靠的、非侵入性的肾脏疾病活动和治疗反应的生物标志物来确定过度治疗和正在治疗之间的正确平衡。用流式细胞术定量尿白细胞是各种炎症性肾脏疾病的一个即将到来的生物标志物。由于T调节细胞(Treg)和Th17细胞在AAV中的致病作用正在显现，我们推测这些T细胞亚群可能是AAV疾病活动性的潜在生物标志物。方法：采用流式细胞术检测AAV患者(活动期伴/不伴肾脏受累、病情稳定缓解)和健康对照组尿T淋巴细胞及其亚群(Th17、Treg)。
Background: Necrotizing crescentic glomerulonephritis (NCGN) is a major contributor to morbidity and mortality in ANCA-associate vasculitis (AAV). As therapy relies on cytotoxic agents with potential adverse effects, a reliable non-invasive biomarker of renal disease activity and therapeutic response is needed to determine the right balance between over-and under treatment. Quantification of urinary leukocytes by flow cytometry is an upcoming biomarker in various inflammatory renal diseases. Since the pathogenic role of T regulatory (Treg) and Th17 cells in AAV is emerging, we hypothesized that these urinary T cell subsets may represent a potential biomarker for renal AAV disease activity.Methods: Urinary T-lymphocytes and their subsets (Th17, Treg) were measured in AAV patients (active with/without renal involvement, stable remission) and healthy controls using flow-cytometry.