Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study
Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study
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DOI：
10.1093/ajcn/87.1.150
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发表时间：
2008-01-01
影响因子：
7.1
通讯作者：
Kritchevsky, Stephen B.
中科院分区：
文献类型：
--
作者：
Houston, Denise K.;Nicklas, Barbara J.;Kritchevsky, Stephen B.
背景资料：膳食调查表明，许多老年人，社区居住的成年人摄入的膳食蛋白质不足，这可能会导致与年龄相关的瘦体重（LM）的损失。目的：本研究的目的是确定膳食蛋白质与老年人，社区居住的男性和女性总LM和非骨表LM（aLM）变化之间的关联。设计：饮食蛋白质摄入量通过使用访谈者管理的108项食物频率问卷在参与健康、衰老和身体组成研究的70-79岁男性和女性中进行评估（n = 2066）。用双能X线吸收法测量3年以上LM和aLM的变化。采用多元线性回归分析对潜在混杂因素进行校正，研究蛋白质摄入量与LM和aLM的3年变化之间的相关性。结果：校正潜在混杂因素后，能量校正的蛋白质摄入量与LM的3年变化相关[β（SE）：8.76（3.00），P = 0.004]和aLM [β（SE）：5.31（1.64），P = 0.001]。蛋白质摄入量最高的五分之一的参与者比蛋白质摄入量最低的五分之一的参与者损失的LM和aLM少约40%（（x）在条形图上+/- SE：LM为-0.501 +/- 0.106 kg，而LM为-0.883 +/- 0.104 kg; aLM为-0.400 +/- 0.058 kg，而aLM为-0.661 +/- 0.057 kg;趋势P < 0.01）。调整后的脂肪量的变化，协会略有衰减，但结果仍然显着。结论：膳食蛋白质可能是一个可修改的风险因素，在老年人肌肉减少症，应进一步研究，以确定其对维护LM在这一人群中的影响。
Background: Dietary surveys suggest that many older, community-dwelling adults consume insufficient dietary protein, which may contribute to the age-related loss of lean mass (LM).Objective: The objective of the study was to determine the association between dietary protein and changes in total LM and nonbone appendicular LM (aLM) in older, community-dwelling men and women.Design: Dietary protein intake was assessed by using an interviewer-administered 108-item food-frequency questionnaire in men and women aged 70-79 y who were participating in the Health, Aging, and Body Composition study (n = 2066). Changes in LM and aLM over 3 y were measured by using dual-energy X-ray absorptiometry. The association between protein intake and 3-y changes in LM and aLM was examined by using multiple linear regression analysis adjusted for potential confounders.Results: After adjustment for potential confounders, energy-adjusted protein intake was associated with 3-y changes in LM [beta (SE): 8.76 (3.00), P = 0.004] and aLM [beta (SE): 5.31 (1.64), P = 0.001]. Participants in the highest quintile of protein intake lost approximate to 40% less LM and aLM than did those in the lowest quintile of protein intake ((x) over bar +/- SE: -0.501 +/- 0.106 kg compared with -0.883 +/- 0.104 kg for LM; -0.400 +/- 0.058 kg compared with -0.661 +/- 0.057 kg for aLM; P for trend < 0.01). The associations were attenuated slightly after adjustment for change in fat mass, but the results remained significant.Conclusion: Dietary protein may be a modifiable risk factor for sarcopenia in older adults and should be studied further to determine its effects on preserving LM in this population.