Control of alcohol metabolism.
Control of alcohol metabolism.
复制标题
控制酒精代谢。
DOI：
10.1007/978-3-0348-7330-7_31
复制
发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Plapp,BV
中科院分区：
文献类型：
--
作者：
Plapp,BV
酒精代谢的速度由乙醇和乙醛脱氢酶的动力学特征和浓度以及细胞氧化还原状态的恢复速度决定。几种有效的竞争性和非竞争性乙醇脱氢酶抑制剂可以降低酒精代谢的速度；它们可能有助于防止乙醇代谢的潜在有害影响。乙醇脱氢酶具有非常广泛的专一性，在乙醇代谢的同时，可以很容易地通过交换反应还原各种羰基化合物。需要开发提高新陈代谢速度的药物。
The rate of alcohol metabolism is determined by the kinetic characteristics and concentrations of the alcohol and aldehyde dehydrogenases and by the rate of restoration of the redox state of the cell. Several potent competitive and uncompetitive inhibitors of the alcohol dehydrogenases can decrease the rate of alcohol metabolism; they may be useful for preventing the potentially deleterious effects of ethanol metabolism. Alcohol dehydrogenases have very broad specificity and can readily reduce a variety of carbonyl compounds by exchange reactions while ethanol is metabolized. Agents that increase the rate of metabolism need to be developed.