Keto analogue and amino acid supplementation affects the ammonaemia response during exercise under ketogenic conditions
Keto analogue and amino acid supplementation affects the ammonaemia response during exercise under ketogenic conditions
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DOI：
10.1017/s000711451000557x
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发表时间：
2011-06-01
影响因子：
3.6
通讯作者：
Cameron, Luiz-Claudio
中科院分区：
文献类型：
--
作者：
Prado, Eduardo Seixas;de Rezende Neto, Jose Melquiades;Cameron, Luiz-Claudio
高氨血症与运动时的中枢性和外周性疲劳有关。运动引起的高氨血症可以通过补充氨基酸或结合酮类类似物和氨基酸（KAAA）来减少。在本研究中，我们确定了短期补充KAAA对低碳水化合物饮食受试者运动时氨生成的影响。共有13名男性自行车手服用生酮饮食3 d，分为两组，分别服用KAAA （KEx）或乳糖（对照组；LEx）补充剂。运动员在室内骑行2小时，并在休息、运动和恢复期的1小时内采集血液样本。运动引起的氨血症在对照组最高可达35%，而补充组无显著升高。两组在运动后尿毒症都有显著增加（约35%）。运动90分钟后，两组的静息尿酸水平相当，且KEx组的静息尿酸水平在统计学上保持不变；在LEx组中观察到较早的增加。无论是在试验期间还是两组之间，血糖水平都没有变化。在运动的前30分钟，两组的乳酸水平都有所增加，但两组之间没有差异。目前的结果表明，急性使用KAAA减少运动引起的高氨血症。
Hyperammonaemia is related to both central and peripheral fatigue during exercise. Hyperammonaemia in response to exercise can be reduced through supplementation with either amino acids or combined keto analogues and amino acids (KAAA). In the present study, we determined the effect of short-term KAAA supplementation on ammonia production in subjects eating a low-carbohydrate diet who exercise. A total of thirteen male cyclists eating a ketogenic diet for 3 d were divided into two groups receiving either KAAA (KEx) or lactose (control group; LEx) supplements. Athletes cycled indoors for 2 h, and blood samples were obtained at rest, during exercise and over the course of 1 h during the recovery period. Exercise-induced ammonaemia increased to a maximum of 35% in the control group, but no significant increase was observed in the supplemented group. Both groups had a significant increase (approximately 35%) in uraemia in response to exercise. The resting urate levels of the two groups were equivalent and remained statistically unchanged in the KEx group after 90 min of exercise; an earlier increase was observed in the LEx group. Glucose levels did not change, either during the trial time or between the groups. An increase in lactate levels was observed during the first 30 min of exercise in both groups, but there was no difference between the groups. The present results suggest that the acute use of KAAA diminishes exercise-induced hyperammonaemia.